miRNA expressions and mixes of independent components. There are three experimental conditions: Pdx-1 induction (dox treatment), IL-1β treatment and time (samples are taken 2 h and 24 h after treatment). (A) Log2-transformed fold changes (mean and standard deviations) between experimental and control (untreated cells) conditions. *: 0.05 > q > 0.01, **: 0.01 > q > 0.001, ***: 0.001 > q > 0. (B) For each independent component (IC) the average of mixes are shown for each condition. Bars represent mean and standard deviation. IC1 is a Pdx-1 component showing mixes correlating to Pdx-1 induction. IC 2 and 3 are cytokine components with mixes correlating to IL-1β treatment. IC 4 shows mixes correlating to induction of Pdx-1 and treatment with IL-1β after 24 h. IC 5 has mixes increasing from 2 h to 24 h in all three conditions. (C) The coefficient for the linear combination of the ICs giving the best fit of the miRNA expressions. The coefficients are scaled to have an absolute sum of one.