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Table 5 Tool Performance Across 19 Proteins in Each of the 1990 Core Ortholog Groups

From: Genome-wide protein localization prediction strategies for gram negative bacteria

Test

Tool

Groups with no match

Disagree with Curation

Groups with match

Disagree with Curation

Groups with mixed predictions

Curated as having Match

Sig Pep cleaved by LspA

LipoP 1.0

1911

0

49

0

30

61

Sig Pep cleaved by LepB

SignalP-NN 3.0

1482

4

158

39

350

169

Sig Pep cleaved by LepB

SignalP-Hmm 3.0

1447

1

247

89

296

 

Sig Pep recognized by TAT

TatP 1.0

1962

0

5

2

23

5

Inner membrane protein

TmHmm 2.0

1417 (1)1

1

390 (103)

21

183 (29)

403 (133)

Inner membrane protein

Phobius

1505 (14)

14

349 (72)

7

136 (47)

 

Outer membrane protein

Bomp

1934

11

13

2*

43

32

  1. 1Values in parentheses indicate number of proteins predicted to have only 1 transmembrane span.