In silico prediction of the granzyme B degradome

BMC Genomics

Table 4 Prediction of granzyme B cleavage of CHIKV proteome

Protein	Biological activity and function	Cleavage sites*
NSP1	Non-structural: mRNA capping	9, 11, 58, 525
NSP2	Non-structural: NTPase, helicase and protease activities	116, 247, 343
NSP3	Non-structural: ADP-ribose phosphatase activity	181, 350, 363, 506
NSP4	Non-structural: RNA polymerase activity	219, 371, 476, 540
E1	Structural: virus-host cell fusion	Nil
E2	Structural: virus-host cell attachment	77
E3	Structural: unknown	Nil
Capsid	Structural: protease, viral nucleocapsid formation	112, 174
6K	Structural: membrane permeabilization, budding of viral particles	Nil

*Position of the P₁ residue on the substrate. All predicted cleavage sites contain Asp at P₁. Underlines indicate P₁ location in the functional domain(s) of protein.

ISSN: 1471-2164