Prevalence and classification of hub proteins using co-expression correlation and stability. Frequency of hubs in proteins with varying levels of co-expression correlation and stability with their interaction partners. Gray regions indicate the absence of proteins for that window of correlation and stability values. Hub proteins are divided into 4 categories as shown. Category 1 – correlation > 0.5, stability > 0.5; Category 2 – correlation <= 0.5, stability > 0.5; Category 3 – correlation <= 0.5, stability <= 0.5; Category 4 – correlation > 0.5, stability <= 0.5. Refer Figure S1c in Additional File 1 for standard error values.