Assessing the utility of gene co-expression stability in combination with correlation in the analysis of protein-protein interaction networks

Table 1 Network characteristics of hub proteins in 3 categories.

Type	Average clustering coefficient	Average betweenness centrality (10^-4)
Category 1 (41 hubs)	0.231 ±0.017*	5.56 ±0.53
Category 2 (264 hubs)	0.099 ±0.016	36.32 ±2.41
Category 3 (315 hubs)	0.154 ±0.004	10.91 ±2.79

Average clustering coefficient and betweenness centrality for 3 categories of hubs based on co-expression correlation and stability. Category 1 – correlation > 0.5, stability > 0.5; Category 2 – correlation <= 0.5, stability > 0.5; Category 3 – correlation <= 0.5, stability <= 0.5. Differences in the distributions of Hub categories 1, 2 and 2, 3 are statistically significant at p << 0.001.
* 95% confidence intervals for average clustering coefficient and betweenness centrality for hubs in each category.

ISSN: 1471-2164