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Figure 8 | BMC Genomics

Figure 8

From: A robust tool for discriminative analysis and feature selection in paired samples impacts the identification of the genes essential for reprogramming lung tissue to adenocarcinoma

Figure 8

GeneGo disease association analysis. Sorting of the GO term enrichment is done by p-values. The p-value is estimated by GeneGo MetaCore ‘Statistically significant Diseases’ method. Yellow: cluster 1, blue: cluster 2, read: cluster 3, and green: cluster 4. Selected genes of the GO clusters are described in Table 2. Cluster 1 (top) includes genes of Inflammatory response, Regulation of cytoskeleton organization, Positive regulation of response to stimulus, Wound healing, Response to mechanical stimulus, Negative regulation of cell proliferation, Regulation of locomotion, Complement activation, Positive regulation of immune response, Hormonal immune response. These genes are suppressed in AC vs AT. Cluster 2 includes the genes of M phase of mitotic cell cycle, Negative regulation of intracellular transport, Microtubule-based process, Response to DNA damage stimulus, Spindle organization, Cellular protein localization DNA repair, Glycosylation. These genes are overexpressed in AC vs AT. Cluster 3 includes the genes of Enzyme linked receptor protein signalling pathway, Metal ion homeostasis, Protein amino acid phosphorylation, Transmembrane receptor protein tyrosine kinase signalling pathway, Negative regulation of cell proliferation. These genes are suppressed in AC vs AT. Cluster 4 includes the genes of Collagen fibril organization, Collagen metabolic process, Glycolysis, Carbohydrate catabolic process, Extracellular structure organization, Negative regulation of cell adhesion, Generation of precursor metabolites and energy, Negative regulation of protein ubiquitination. Cluster 4 includes the genes up-regulated in AC vs AT (Figure 7).

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BMC Genomics

ISSN: 1471-2164

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