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Table 5 PT-AT discriminative set and its extended set are significantly enriched by gene markers reported as potential biomarkers for a diagnostic of the early stages of lung AC. The extended set was obtained by relaxing the default PT-AT ECD signature at misclassification error values to 3. More details in see Additional file 4.

From: A robust tool for discriminative analysis and feature selection in paired samples impacts the identification of the genes essential for reprogramming lung tissue to adenocarcinoma

Early AC diagnostic signature genes from [7]# Supporting references# PT-AT extreme discriminative sign. (2829 genes) Extended set (misclassification errors to 3) EDGE
ATP10B [7] YES YES NO
AURKA [5][7] YES YES YES
CLDN5 [7] YES YES YES
COL11A1 [10][7] YES YES YES
DNAI2 [7] NO YES NO
FABP6 [7] NO NO NO
HIGD1B [7] YES YES YES
ILF3 [5][17][2] YES YES NO
IQCG [7] NO NO NO
LRRC48 [7] NO NO NO
LRRC50 [7] NO NO NO
MCM6 [5][7] YES YES NO
MUC4 [13][7] NO YES NO
RARRES2 [7][3] YES YES YES
RFTN1 [22][7][4][3] YES YES NO
SCG5 [7] YES YES NO
SCGB1A1 [9][7] NO YES YES
SFTPA2 [7] YES YES NO
SFTPB [7] NO YES NO
SFTPC [7] YES YES YES
TFPI2 [7] YES YES YES
TM4SF4 [7] NO YES NO
TOP2A [5][7][6] YES YES YES
XAGE1A [14][7] YES YES YES
XAGE1B [24][21][14][7] no U133A probe sets no U133A probe sets no U133A probe sets
XAGE1C [14][7] no U133A probe sets no U133A probe sets no U133A probe sets
XAGE1D [14][7] no U133A probe sets no U133A probe sets no U133A probe sets
XAGE1E [14][7] no U133A probe sets no U133A probe sets no U133A probe sets
  1. # - The references mentioned in this table correspond to the citations used in Additional file 4.