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Table 3 Biological associations between genes and breast cancer

From: Maximizing biomarker discovery by minimizing gene signatures

Gene General description Support Endpoint D Endpoint E
    Overlap Position Overlap Position
CA12 Highly correlated with Erα + 67 -5 61 4
MAPT prognostic values in ER(+) Primary breast cancers in 3 patient cohorts + 43 -7 22 26
ESR1 Involved in pathological processes of breast cancer + 33 -2 53 1
GATA3 A breast cancer marker + 25 -14 40 6
BTG3 Protein coding   22 75   -142
NFIB Differentially expressed reported [39]   22 84 20 -61
LDHB Protein coding   21 27   -239
RARRES1 Downregulated reported [40]   20 2 19 -2
CCND1 Aberrantly regulated and could contribute to therapeutic failure in the context of ER-positive breast cancer + 18 -56   145
ELF5 Downregulated reported [41]   16 7   -16
IL6ST Protein coding    -60 33 60
SLC39A6 Coregulated with estrogen receptor in some breast cancers +   -64 25 41
TBC1D9 Protein coding    -25 25 19
ABAT Protein coding    -34 16 29
  1. Genes marked '+' indicates experimental support for a role in breast cancer in Support. Unless otherwise stated, descriptions were collected from Entrez Gene [25]. Numbers in the Overlap reflect number of gene overlap, for the top 10 ranked genes of two endpoints. Values for Position reflect these genes' rank in the descending sorted list of fold-change values, signs of which represent gene positions in the two ends of the list. Almost all top 10 genes for each endpoint rank in the top 200 up-regulated or down-regulated genes. Furthermore, among the genes common to these two endpoints, the change in expression level was not always correlated. In other words, genes up-regulated in endpoint D could be down-regulated in endpoint E.