Table 2 Representative P. falciparum proteins that are associated with the regulated intramembrane proteolysis (RIP) network.
From: Protease-associated cellular networks in malaria parasite Plasmodium falciparum
Protease family | Accession number of protease | Associated Protein accession number | Annotation |
|---|---|---|---|
A22 (presenilin family) | PF14_0543 | PFI0150c | putative retrieval receptor for endoplasmic reticulum membrane proteins |
| Â | Â | PF13_0280 | ER lumen protein retaining receptor |
| Â | Â | MAL13P1.231 | Sec61 alpha subunit, PfSec61 |
| Â | Â | PFB0450w | secretory complex protein 61 gamma subunit |
| Â | Â | PF11_0447 | putative translation initiation factor eIF-1A |
| Â | Â | PF10_0077 | putative eukaryotic translation initiation factor 3 subunit 7 |
| Â | Â | PFL0310c | putative eukaryotic translation initiation factor 3 subunit 8 |
| Â | Â | PFL0335c | putative eukaryotic translation initiation factor 5 |
| Â | Â | PFE1405c | putative eukaryotic translation initiation factor 3, subunit 6 |
| Â | Â | PFC0870w | putative elongation factor 1 (EF-1) |
| Â | Â | MAL8P1.48 | putative splicing factor |
| Â | Â | PFB0550w | putative peptide chain release factor subunit 1 |
| Â | Â | PF07_0034 | cloroquine resistance associated protein Cg3 protein |
| Â | Â | PF13_0022 | cyclin |
S54 (Rhomboid family) | PF11_0150 | PF11_0344 | apical membrane antigen 1 |
| Â | Â | PF11_0486 | merozoite adhesive erythrocytic binding protein |
| Â | Â | PFA0125c | erythrocyte binding antigen-181 |
| Â | Â | MAL13P1.60 | erythrocyte binding antigen-140 |
| Â | Â | MAL7P1.176 | erythrocyte binding antigen-175 |
| Â | Â | MAL13P1.176 | reticulocyte binding protein 2 homolog b |
M50 (S2P protease family) | PF13_0028 | PF13_0287 | adenylosuccinate synthetase |
| Â | PF10_0317 | PFB0260w | putative proteasome 26S regulatory subunit |
| Â | Â | PFF0940c | putative cell division cycle protein 48 homolog |