Figure 2

Analysis of placenta-enriched and -specific genes. (a) Number of tissue-enriched (blue bar) and tissue-specific (red bar) genes. Tissue-enriched genes were defined as genes with more than 4-fold change in expression and minimum FPKM of 1. (b) Proportions of overlapping genes between the placenta-enriched gene list and the MGI or PTB gene list (see text and Methods for details). The lighter shade indicates the proportion of non-placentaenriched genes while the darker shade indicates the proportion of placenta-enriched genes. P-values were determined by Fisher's exact test. (c) Expression profile of the 70 placenta-enriched MGI list genes. Gene expression values were normalized for each gene and color-coded using the same scheme depicted in Figure 1. (d) Expression patterns of placenta-specific genes in amnion, chorion, and decidua. Color scheme is based on log10(FPKM value).