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Figure 4 | BMC Genomics

Figure 4

From: A searchable cross-platform gene expression database reveals connections between drug treatments and disease

Figure 4

Enrichment plots for high scoring SPIED hits against the glucocorticoid (dexamethasone) resistant v sensitive profile query. The dexamethasone resistance query scores highly against a corticosteroid (prednisolone) resistance study. The enrichment plot is shown in A. Ordering the samples according to correlation score with the query profile the enrichment plot is the cumulative fraction of the given phenotype in the given sample fraction. Explicitly, if there are N correlation score ordered samples and two phenotypes defined by q i = ± 1 with i = 1,...,N, then the enrichment for the phenotypes is e k + - = ± ∑ i = 1 k q i ∑ i = 1 N q i and the enrichment plot is just e k + - against k N . The plot shows that sensitive samples are enriched for lower correlation scores and resistant samples are enriched for higher correlation scores. The enrichment plots for the lung cancer study is shown in B and for the pancreatic cancer study in C.

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