A searchable cross-platform gene expression database reveals connections between drug treatments and disease

BMC Genomics

Table 4 Rodent correlations with the severe AD profile.

	Mouse spinal chord injury v sham at injury site
	4 h		24 h		72 h		7 d		28 d
	R	N	r	N	r	N	r	N	r	N
severe	0.12	55	0.26	131	0.60	148	0.55	148	0.62	139
moderate	-0.08	66	0.12	138	0.45	162	0.47	164	0.52	129
incipient	-0.07	37	-0.08	62	0.31	92	0.25	82	0.34	77
	Rat chronic spinal chord contusion			Prion infection neurodegeneration			SOD1(G93A)
							young 28-40d		old 112-126d
	r	N		r	N		r	N	r	N
severe	0.76	76		0.70	176		0.07	109	0.49	205
moderate	0.63	63		0.66	158		-0.01	114	0.42	210
incipient	0.50	26		0.11	71		-0.08	76	0.19	105

The severe AD profile is significantly correlated with four different rodent models of neurodegeneration and nerve injury. The correlation in the spinal chord injury time course study emerges at 72 hours. The ALS SOD1(G93A) profile correlation is only seen with late stage disease.

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