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Table 5 Multi-species derived nerodegenerative signature.

From: A searchable cross-platform gene expression database reveals connections between drug treatments and disease

Gene

signature

A

B

C

D

E

VSNL1

-1

-1.20

-1.19

-0.28

-0.28

-0.50

NEFL

-1

-1.06

-0.72

-0.23

-0.42

-0.60

CCK

-1

-0.91

-1.12

-0.47

-0.23

-0.85

YWHAH

-1

-0.88

-0.38

-0.26

-0.17

-0.39

TUBA4A

-1

-0.75

-0.80

-0.45

-0.32

-0.23

YWHAB

-1

-0.73

-0.39

-0.72

-0.21

-0.40

NRN1

-1

-0.67

-0.65

-0.67

-0.31

-0.76

GUCY1B3

-1

-0.66

-0.64

-0.30

-0.22

-0.13

SCN1A

-1

-0.60

-1.05

-0.62

-0.36

-0.35

SYP

-1

-0.54

-0.62

-0.49

-0.26

-0.25

NDRG3

-1

-0.52

-0.58

-0.31

-0.17

-0.33

PPP2R2B

-1

-0.42

-0.66

-0.51

-0.25

-0.27

MDH2

-1

-0.42

-0.36

-0.28

-0.13

-0.12

DYNC1I1

-1

-0.39

-1.00

-0.71

-0.35

-0.47

RHOC

+1

0.30

0.39

1.03

0.73

0.74

SLC16A1

+1

0.35

0.36

0.69

0.48

0.20

MAPKAPK2

+1

0.40

0.32

0.51

0.37

0.23

CTSB

+1

0.43

0.79

0.80

0.86

0.57

DAB2

+1

0.47

1.05

0.94

0.58

0.29

CLU

+1

0.47

0.54

0.37

0.50

0.22

TBC1D2B

+1

0.51

0.32

0.42

0.18

0.76

ZFP36L1

+1

0.61

0.59

0.98

0.56

0.48

SREBF1

+1

0.63

0.90

0.57

0.36

0.46

MDFIC

+1

0.63

0.80

1.43

1.17

0.43

  1. The AD based signature consists of a set of down-regulated (-1) and up-regulated (+1) genes based on the conservation of gene sense change across multiple expression studies of neurodegeneration. The five expression profile fold values are shown with: A, severe AD in human; B, chronic spinal chord contusion in rat; C, chronic spinal chord contusion in mouse; D, SOD1(G93A) mutation late stage in mouse; E, prion disease in mouse.