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Table 2 50 PFAM categories most expanded in the Mtb clade relative to the non-pathogenic, soil-dwelling Mycobacteria

From: Comparative analysis of mycobacterium and related actinomycetes yields insight into the evolution of mycobacterium tuberculosis pathogenesis

PFAM name PFAM ID p-valuea inter-to-intra-
centroid difference
b PIN domain PF01850 4.20E-09 1.10E+01
GHMP kinases C terminal PF08544 1.00E-08 8.80E+00
DHHA1 domain PF02272 2.10E-08 6.80E+00
KGG Stress-induced bacterial acidophilic repeat motif PF10685 6.70E-08 6.20E+00
b Protein of unknown function (DUF1396) (lipoproteins within cell wall) PF07161 4.10E-07 9.20E+00
b Rv0623-like transcription factor (toxin-antitoxin-related) PF07704 9.30E-07 1.00E+01
Tetratricopeptide repeat PF07720 9.90E-07 8.60E+00
PA domain PF02225 1.00E-06 6.40E+00
c Patatin-like phospholipase PF01734 1.20E-06 9.20E+00
e Protein of unknown function (DUF1490) PF07371 1.20E-06 1.00E+01
4 FAD binding domain PF01565 1.30E-06 6.40E+00
Fumarate reductase/succinate dehydrog. flavoprotein C-term domain PF02910 1.50E-06 5.90E+00
FIST C domain PF10442 2.00E-06 1.20E+01
Corticotropin ACTH domain PF00976 2.30E-06 6.00E+00
c Beta-ketoacyl synthase, N-terminal domain PF00109 2.40E-06 5.00E+00
IlvB leader peptide PF08049 4.20E-06 3.50E+00
c Beta-ketoacyl synthase, C-terminal domain PF02801 4.50E-06 4.80E+00
c Acyl transferase domain PF00698 4.60E-06 5.20E+00
b PPE family (antigenic variability) PF00823 5.60E-06 1.00E+01
b Proteins of 100 residues with WXG (esx-related) PF06013 7.10E-06 7.90E+00
b Phd YefM (toxin-antitoxin-related) PF02604 7.70E-06 9.00E+00
Ponericin PF07442 7.70E-06 8.70E+00
b Plasmid stabilization system protein (toxin-antitoxin-related) PF05016 9.90E-06 9.30E+00
Threonine leader peptide PF08254 1.10E-05 8.90E+00
Toxin 33 Waglerin family PF08121 2.20E-05 3.20E+00
Phosphatidylethanolamine-binding protein PF01161 2.20E-05 7.30E+00
b PemK-like protein (toxin-antitoxin-related) PF02452 3.10E-05 9.00E+00
Erythronolide synthase docking PF08990 5.60E-05 7.30E+00
d Radical SAM superfamily PF04055 5.80E-05 3.90E+00
d ThiS family PF02597 6.60E-05 5.60E+00
b Pentapeptide repeats (8 copies) PF01469 1.20E-04 1.00E+01
Rubredoxin PF00301 1.30E-04 3.80E+00
d Pterin 4 alpha carbinolamine dehydratase PF01329 1.50E-04 8.80E+00
Leucine rich repeat N-terminal domain PF01462 1.60E-04 1.00E+01
e Domain of unknown function (DUF1610) PF07754 2.10E-04 2.40E+00
SEC-C motif PF02810 2.30E-04 3.00E+00
d MoaC family PF01967 2.60E-04 7.10E+00
Berberine and berberine like PF08031 2.70E-04 9.30E+00
Cytochrome B6-F complex subunit VI (PetL) PF05115 2.80E-04 9.40E+00
Region found in RelA/SpoT proteins PF04607 3.00E-04 5.00E+00
Quinolinate phosphoribosyl transferase, C-terminal domain PF01729 3.30E-04 4.20E+00
Fumarate reductase subunit C PF02300 3.70E-04 1.00E+01
LHC Antenna complex alpha/beta subunit PF00556 5.00E-04 3.20E+00
RNPHF zinc finger PF08080 5.10E-04 6.50E+00
Protein of unknown function (DUF1416) PF07210 5.20E-04 9.60E+00
PsbJ PF01788 5.40E-04 3.70E+00
Bacterial transferase hexapeptide (three repeats) PF00132 5.50E-04 3.00E+00
N Chalcone and stilbene synthases, N-terminal domain PF00195 6.60E-04 8.40E+00
d MoaE protein PF02391 8.00E-04 7.80E+00
b Protein of unknown function (DUF1066) (esx) PF06359 8.30E-04 1.10E+01
  1. a Bonferroni-corrected p-value calculated from T-test
  2. b pathogenicity or survival within the host
  3. c Lipid metabolism
  4. d Pterin cofactor biosynthesis
  5. e unknown function