Table 3 The 50 GO terms most expanded in the Mtb clade relative to the non-pathogenic, soil-dwelling Mycobacteria
GO descriptor | GO term ID | p-valuea | inter-to-intra centroid difference |
|---|---|---|---|
4-hydroxy-3-methylbut-2-en-1-yl diphosphate red. activity | GO_0051745 | 4.80E-08 | 7.20E+00 |
dTMP biosynthetic process | GO_0006231 | 7.30E-07 | 4.40E+00 |
response to cAMP | GO_0051591 | 1.40E-06 | 1.20E+01 |
succinate dehydrogenase (ubiquinone) activity | GO_0008177 | 1.70E-06 | 5.10E+00 |
iron ion transport | GO_0006826 | 2.70E-06 | 4.70E+00 |
magnesium ion binding | GO_0000287 | 2.80E-06 | 1.70E+00 |
c fatty-acyl-CoA synthase activity | GO_0004321 | 5.10E-06 | 6.50E+00 |
c acyltransferase activity | GO_0008415 | 7.60E-06 | 3.60E+00 |
transferase activity, transferring alkyl or aryl (other than methyl) groups | GO_0016765 | 1.30E-05 | 2.60E+00 |
c tricarboxylic acid cycle | GO_0006099 | 1.30E-05 | 3.40E+00 |
d Mo-molybdopterin cofactor biosynthetic process | GO_0006777 | 1.40E-05 | 6.30E+00 |
integral to membrane | GO_0016021 | 2.00E-05 | 2.00E+00 |
acid phosphatase activity | GO_0003993 | 2.50E-05 | 3.20E+00 |
phosphatase activity | GO_0016791 | 3.20E-05 | 4.10E+00 |
erythronolide synthase activity | GO_0047879 | 4.20E-05 | 8.20E+00 |
d 4-alpha-hydroxytetrahydrobiopterin dehydratase activity | GO_0008124 | 6.80E-05 | 6.20E+00 |
c lipid metabolic process | GO_0006629 | 6.80E-05 | 4.70E+00 |
bacteriochlorophyll biosynthetic process | GO_0030494 | 7.00E-05 | 1.30E+00 |
plasma membrane | GO_0005886 | 7.10E-05 | 2.70E+00 |
d tetrahydrobiopterin biosynthetic process | GO_0006729 | 1.10E-04 | 8.80E+00 |
c lipid biosynthetic process | GO_0008610 | 1.20E-04 | 3.50E+00 |
phosphatidylcholine metabolic process | GO_0046470 | 1.60E-04 | 9.50E+00 |
c geranyltranstransferase activity | GO_0004337 | 1.60E-04 | 6.80E+00 |
cytoplasm | GO_0005737 | 1.90E-04 | 1.40E+00 |
protein transport | GO_0015031 | 1.90E-04 | 1.70E+00 |
guanosine tetraphosphate metabolic process | GO_0015969 | 2.20E-04 | 5.00E+00 |
glyoxylate cycle | GO_0006097 | 2.20E-04 | 4.30E+00 |
phosphoglycolate phosphatase activity | GO_0008967 | 2.80E-04 | 4.30E+00 |
terpenoid biosynthetic process | GO_0016114 | 3.90E-04 | 2.80E+00 |
sulfur metabolic process | GO_0006790 | 4.10E-04 | 5.30E+00 |
4 iron, 4 sulfur cluster binding | GO_0051539 | 5.00E-04 | 2.90E+00 |
succinate dehydrogenase activity | GO_0000104 | 5.70E-04 | 4.60E+00 |
b mycocerosate synthase activity | GO_0050111 | 5.80E-04 | 4.10E+00 |
c phospholipid biosynthetic process | GO_0008654 | 6.10E-04 | 2.30E+00 |
nucleoside metabolic process | GO_0009116 | 6.30E-04 | 3.60E+00 |
c phosphopantetheine binding | GO_0031177 | 8.20E-04 | 3.00E+00 |
adenylate cyclase activity | GO_0004016 | 8.30E-04 | 5.50E+00 |
D-arabinono-1,4-lactone oxidase activity | GO_0003885 | 9.70E-04 | 8.40E+00 |
anaerobic respiration | GO_0009061 | 9.90E-04 | 1.10E+01 |
nodulation | GO_0009877 | 1.10E-03 | 7.10E+00 |
c prenyltransferase activity | GO_0004659 | 1.10E-03 | 4.20E+00 |
c lysophospholipase activity | GO_0004622 | 1.30E-03 | 8.50E+00 |
c acetyl-CoA carboxylase activity | GO_0003989 | 1.30E-03 | 2.40E+00 |
histidinol-phosphatase activity | GO_0004401 | 2.10E-03 | 6.50E+00 |
pyridine nucleotide biosynthetic process | GO_0019363 | 2.30E-03 | 5.00E+00 |
NAD biosynthetic process | GO_0009435 | 3.30E-03 | 1.30E+00 |
lactate fermentation to propionate and acetate | GO_0019652 | 3.40E-03 | 3.40E+00 |
alkylglycerone-phosphate synthase activity | GO_0008609 | 3.40E-03 | 7.10E+00 |
b cyclopropane-fatty-acyl-phospholipid synthase activity | GO_0008825 | 4.00E-03 | 5.90E+00 |
methylcrotonoyl-CoA carboxylase activity | GO_0004485 | 4.40E-03 | 3.00E+00 |