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Table 5 The 50 GO terms most expanded in the Mycobacteria relative to the non- Mycobacteria

From: Comparative analysis of mycobacterium and related actinomycetes yields insight into the evolution of mycobacterium tuberculosis pathogenesis

GO term descriptor GO term ID p-valuea inter-to-intra-centroid difference
c sterol biosynthetic process GO:0016126 1.00E-10 1.80E+01
b regulation of apoptosis GO:0042981 1.10E-10 1.90E+01
c 3alpha,7alpha,12alpha-trihydroxy-5beta- cholest-24-enoyl-CoA hydratase activity GO:0033989 1.40E-10 1.70E+01
c linalool 8-monooxygenase activity GO:0050056 1.50E-10 1.70E+01
c sterol 14-demethylase activity GO:0008398 5.10E-09 1.60E+01
c cutinase activity GO:0050525 5.80E-09 1.60E+01
oxidoreductase activity, acting on NADH or NADPH, nitrogenous group as acceptor GO:0016657 1.80E-08 1.40E+01
c diacylglycerol O-acyltransferase activity GO:0004144 2.10E-08 1.70E+01
ligase activity, forming carbon-carbon bonds GO:0016885 6.10E-08 1.40E+01
indolylacetylinositol arabinosyltransferase activity GO:0050409 7.90E-08 1.20E+01
c 4-hydroxy-2-oxovalerate aldolase activity GO:0008701 1.00E-07 1.10E+01
arylamine N-acetyltransferase activity GO:0004060 2.80E-07 1.70E+01
c lipid transport GO:0006869 5.00E-07 1.70E+01
c lipid biosynthetic process GO:0008610 5.00E-07 8.50E+00
biphenyl-2,3-diol 1,2-dioxygenase activity GO:0018583 1.40E-06 9.50E+00
cis-stilbene-oxide hydrolase activity GO:0033961 1.50E-06 1.20E+01
c acyl-[acyl-carrier-protein] desaturase activity GO:0045300 1.70E-06 1.00E+01
5-carboxymethyl-2-hydroxymuconic-semialdehyde dehydrog activity GO:0018480 2.00E-06 1.20E+01
c fatty-acyl-CoA synthase activity GO:0004321 2.10E-06 1.20E+01
c steroid biosynthetic process GO:0006694 2.30E-06 1.20E+01
c propanoyl-CoA C-acyltransferase activity GO:0033814 2.50E-06 1.20E+01
extracellular matrix binding GO:0050840 2.70E-06 1.30E+01
lipid glycosylation GO:0030259 6.70E-06 5.60E+00
d coenzyme F420-dependent N5, N10-methenyltetrahydromethanopterinreductase activity GO:0018537 6.90E-06 1.20E+01
C-terminal protein amino acid methylation GO:0006481 1.10E-05 1.10E+01
metabolic process GO:0008152 1.30E-05 4.60E+00
4-oxalocrotonate decarboxylase activity GO:0047437 1.70E-05 1.10E+01
oxidoreductase activity GO:0016491 1.80E-05 5.20E+00
oxidation reduction GO:0055114 1.90E-05 4.80E+00
defense response to bacterium GO:0042742 2.40E-05 1.60E+01
b cyclopropane-fatty-acyl-phospholipid synthase activity GO:0008825 2.90E-05 9.80E+00
c 3-hydroxy-2-methylbutyryl-CoA dehyd. activity GO:0047015 3.40E-05 1.10E+01
nutrient reservoir activity GO:0045735 3.40E-05 9.30E+00
structural constituent of cell wall GO:0005199 3.60E-05 7.90E+00
2-nitropropane dioxygenase activity GO:0018580 4.10E-05 1.40E+01
adenylate cyclase activity GO:0004016 6.00E-05 9.50E+00
b beta-lactam antibiotic catabolic process GO:0030655 6.70E-05 1.40E+01
DNA primase activity GO:0003896 8.40E-05 1.10E+01
cyclic nucleotide biosynthetic process GO:0009190 8.50E-05 9.80E+00
iron ion transport GO:0006826 8.70E-05 1.20E+01
di-, tri-valent inorganic cation transmembrane transporter activity GO:0015082 9.00E-05 6.80E+00
phosphorus-oxygen lyase activity GO:0016849 1.60E-04 9.50E+00
limonene-1,2-epoxide hydrolase activity GO:0018744 1.60E-04 7.80E+00
c fatty acid metabolic process GO:0006631 1.70E-04 8.40E+00
sirohydrochlorin cobaltochelatase activity GO:0016852 1.80E-04 1.50E+01
intracellular signaling cascade GO:0007242 2.00E-04 8.80E+00
c enoyl-CoA hydratase activity GO:0004300 2.30E-04 1.30E+01
di-, tri-valent inorganic cation transport GO:0015674 2.40E-04 6.20E+00
c acyl-CoA dehydrogenase activity GO:0003995 2.60E-04 9.10E+00
catechol O-methyltransferase activity GO:0016206 3.20E-04 1.50E+01
  1. aBonferroni-corrected p-value calculated from T-test
  2. b pathogenicity or survival within the host
  3. c Lipid metabolism
  4. d Cofactor biosynthesis
  5. e unknown function