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Table 1 Genes upregulated in the total RNA fraction in the presence of wild-type and mutant Tax proteins

From: Identification of bovine leukemia virus tax function associated with host cell transcription, signaling, stress response and immune response pathway by microarray-based gene expression analysis

Gene ID Gene description Gene Symbol Fold Change
    TaxWT TaxS240P TaxD24G
  Transcription/Translation/RNA processing     
1390 cAMP responsive element modulator CREM 2.2 1.8 3.2
1958 early growth response 1 EGR1 1.9 2.0 1.7
22936 elongation factor, RNA polymerase II, 2 ELL2 2.2 2.2 2.2
2119 ets variant 5 ETV5 3.7 3.6 3.4
2353 FBJ murine osteosarcoma viral oncogene homolog FOS 3.7 2.4 4.6
8061 FOS-like antigen 1 FOSL1 2.4 2.4 2.3
3280 Hairy and enhancer of split 1 (Drosophila) HES1 1.8 1.9 2.0
3725 jun oncogene JUN 4.7 5.9 5.3
10365 Kruppel-like factor 2 (lung) KLF2 2.6 2.6 2.8
1316 Kruppel-like factor 6 KLF6 2.1 2.1 2.1
9935 v-maf musculoaponeurotic fibrosarcoma oncogene homolog B (avian) MAFB 2.6 1.9 3.8
23764 v-maf musculoaponeurotic fibrosarcoma oncogene homolog F (avian) MAFF 2.4 1.9 2.6
4929 nuclear receptor subfamily 4, group A, member 2 NR4A2 3.6 1.5 7.7
57157 Putative homeodomain transcription factor 2 PHTF2 1.9 1.9 2.0
6095 RAR-related orphan receptor A RORA 10.3 2.0 10.6
7538 zinc finger protein 36, C3H type, homolog (mouse) ZFP36 2.8 2.6 2.6
  Signal Transduction     
287 ankyrin 2, neuronal ANK2 2.0 2.0 1.4
9518 growth differentiation factor 15 GDF15 5.0 4.9 5.6
2669 GTP binding protein over expressed in skeletal muscle GEM 14.3 5.0 19.1
10681 guanine nucleotide binding protein (G protein), beta 5 GNB5 2.0 1.2 2.4
2786 guanine nucleotide binding protein (G protein), gamma 4 GNG4 1.8 2.0 1.6
26207 phosphatidylinositol transfer protein, cytoplasmic 1 PITPNC1 1.9 1.7 2.5
5329 plasminogen activator, urokinase receptor PLAUR 2.0 1.7 1.9
5521 protein phosphatase 2 (formerly 2A), regulatory subunit B, beta isoform PPP2R2B 1.3 1.0 2.1
5997 regulator of G-protein signaling 2, 24 kDa RGS2 2.4 1.1 2.4
6004 regulator of G-protein signaling 16 RGS16 2.0 2.0 2.0
6236 Ras-related associated with diabetes RRAD 3.8 2.3 7.9
81848 sprouty homolog 4 (Drosophila) SPRY4 1.9 2.1 1.9
  Inflammatory response/Immune response     
2921 chemokine (C-X-C motif) ligand 3 CXCL3 1.8 2.0 1.8
3269 histamine receptor H1 HRH1 2.5 1.7 1.8
7130 tumor necrosis factor, alpha-induced protein 6 TNFAIP6 20.5 1.3 36.6
  Regulation of cell growth/Regulation of cell proliferation     
183 angiotensinogen (serpin peptidase inhibitor, clade A, member 8) AGT 1.3 1.3 2.3
374 amphiregulin AREG 2.0 2.1 2.3
694 B-cell translocation gene 1, anti-proliferative BTG1 3.3 1.1 3.0
6347 chemokine (C-C motif) ligand 2 CCL2 2.0 1.6 1.6
960 CD44 molecule (Indian blood group) CD44 2.1 2.0 2.3
3491 cysteine-rich, angiogenic inducer, 61 CYR61 4.8 2.0 7.5
2014 epithelial membrane protein 3 EMP3 1.8 1.2 3.1
3589 interleukin 11 IL11 3.6 1.7 5.4
83729 inhibin, beta E INHBE 2.1 3.0 1.9
182 jagged 1 JAG1 2.1 1.8 2.3
3976 leukemia inhibitory factor (cholinergic differentiation factor) LIF 2.2 2.2 2.2
  Apoptosis     
56892 chromosome 8 open reading frame 4 C8orf4 1.2 1.2 2.3
8870 immediate early response 3 IER3 3.3 3.2 3.7
22822 pleckstrin homology-like domain, family A, member 1 PHLDA1 2.5 1.9 3.2
51330 tumor necrosis factor receptor superfamily, member 12A TNFRSF12A 2.0 1.9 2.0
27242 tumor necrosis factor receptor superfamily, member 21 TNFRSF21 2.3 2.1 2.4
  Cell adhesion/Cell-cell adhesion     
6695 sparc/osteonectin, cwcv and kazal-like domains proteoglycan 1 SPOCK1 2.0 1.7 2.1
6696 secreted phosphoprotein 1 SPP1 1.9 2.5 2.1
  Transport     
3039 hemoglobin, alpha 1 HBA1 2.4 2.5 2.4
4884 neuronal pentraxin I NPTX1 2.3 1.2 3.6
6507 solute carrier family 1, member 3 SLC1A3 1.8 2.0 1.8
6533 solute carrier family 6, member 6 SLC6A6 2.2 2.3 1.9
23657 solute carrier family 7, member 11 SLC7A11 2.3 2.4 1.8
  Metabolic process     
384 arginase, type II ARG2 3.2 3.2 3.6
9945 glutamine-fructose-6-phosphate transaminase 2 GFPT2 2.0 2.0 1.9
9388 Lipase, endothelial LIPG 1.9 1.4 2.1
7378 uridine phosphorylase 1 UPP1 2.1 1.8 2.0
  Phosphorylation/Dephosphorylation     
9201 doublecortin-like kinase 1 DCLK1 2.1 2.0 2.1
1843 dual specificity phosphatase 1 DUSP1 3.6 2.4 4.7
51207 dual specificity phosphatase 13 DUSP13 2.2 1.9 2.2
1846 dual specificity phosphatase 4 DUSP4 2.9 3.0 2.9
1847 dual specificity phosphatase 5 DUSP5 2.4 2.4 2.8
1848 dual specificity phosphatase 6 DUSP6 2.4 2.8 2.7
5578 protein kinase C, alpha PRKCA 2.1 1.9 1.8
  Response to stress     
3337 DnaJ (Hsp40) homolog, subfamily B, member 1 DNAJB1 2.7 3.1 2.5
3303 heat shock 70 kDa protein 1A HSPA1A 2.9 4.2 2.8
3310 heat shock 70 kDa protein 6 HSPA6 6.4 15.4 5.3
  Others/Unknown     
202 absent in melanoma 1 AIM1 1.7 1.8 2.1
23237 activity-regulated cytoskeleton-associated protein ARC 2.5 2.3 2.3
1475 cystatin A (stefin A) CSTA 4.6 5.3 5.4
56603 cytochrome P450, family 26, subfamily B, polypeptide 1 CYP26B1 2.1 1.7 2.1
23052 endonuclease domain containing 1 ENDOD1 2.0 2.1 2.1
2201 fibrillin 2 FBN2 2.1 1.6 1.8
10324 kelch repeat and BTB (POZ) domain containing 10 KBTBD10 3.0 1.9 2.4
5270 serpin peptidase inhibitor, clade E, member 2 SERPINE2 2.3 2.3 2.4
4071 transmembrane 4 L six family member 1 TM4SF1 1.9 1.8 2.3
25907 transmembrane protein 158 (gene/pseudogene) TMEM158 2.1 2.4 2.5
7171 tropomysin 4 TPM4 2.5 1.5 3.5
7846 tubulin, alpha 1a TUBA1A 1.9 2.1 1.8