Table 1 Genes upregulated in the total RNA fraction in the presence of wild-type and mutant Tax proteins

Transcription/Translation/RNA processing

1390

cAMP responsive element modulator

CREM

2.2

1.8

3.2

1958

early growth response 1

EGR1

1.9

2.0

1.7

22936

elongation factor, RNA polymerase II, 2

ELL2

2.2

2.2

2.2

2119

ets variant 5

ETV5

3.7

3.6

3.4

2353

FBJ murine osteosarcoma viral oncogene homolog

FOS

3.7

2.4

4.6

8061

FOS-like antigen 1

FOSL1

2.4

2.4

2.3

3280

Hairy and enhancer of split 1 (Drosophila)

HES1

1.8

1.9

2.0

3725

jun oncogene

JUN

4.7

5.9

5.3

10365

Kruppel-like factor 2 (lung)

KLF2

2.6

2.6

2.8

1316

Kruppel-like factor 6

KLF6

2.1

2.1

2.1

9935

v-maf musculoaponeurotic fibrosarcoma oncogene homolog B (avian)

MAFB

2.6

1.9

3.8

23764

v-maf musculoaponeurotic fibrosarcoma oncogene homolog F (avian)

MAFF

2.4

1.9

2.6

4929

nuclear receptor subfamily 4, group A, member 2

NR4A2

3.6

1.5

7.7

57157

Putative homeodomain transcription factor 2

PHTF2

1.9

1.9

2.0

6095

RAR-related orphan receptor A

RORA

10.3

2.0

10.6

7538

zinc finger protein 36, C3H type, homolog (mouse)

ZFP36

2.8

2.6

2.6

Signal Transduction

287

ankyrin 2, neuronal

ANK2

2.0

2.0

1.4

9518

growth differentiation factor 15

GDF15

5.0

4.9

5.6

2669

GTP binding protein over expressed in skeletal muscle

GEM

14.3

5.0

19.1

10681

guanine nucleotide binding protein (G protein), beta 5

GNB5

2.0

1.2

2.4

2786

guanine nucleotide binding protein (G protein), gamma 4

GNG4

1.8

2.0

1.6

26207

phosphatidylinositol transfer protein, cytoplasmic 1

PITPNC1

1.9

1.7

2.5

5329

plasminogen activator, urokinase receptor

PLAUR

2.0

1.7

1.9

5521

protein phosphatase 2 (formerly 2A), regulatory subunit B, beta isoform

PPP2R2B

1.3

1.0

2.1

5997

regulator of G-protein signaling 2, 24 kDa

RGS2

2.4

1.1

2.4

6004

regulator of G-protein signaling 16

RGS16

2.0

2.0

2.0

6236

Ras-related associated with diabetes

RRAD

3.8

2.3

7.9

81848

sprouty homolog 4 (Drosophila)

SPRY4

1.9

2.1

1.9

Inflammatory response/Immune response

2921

chemokine (C-X-C motif) ligand 3

CXCL3

1.8

2.0

1.8

3269

histamine receptor H1

HRH1

2.5

1.7

1.8

7130

tumor necrosis factor, alpha-induced protein 6

TNFAIP6

20.5

1.3

36.6

Regulation of cell growth/Regulation of cell proliferation

183

angiotensinogen (serpin peptidase inhibitor, clade A, member 8)

AGT

1.3

1.3

2.3

374

amphiregulin

AREG

2.0

2.1

2.3

694

B-cell translocation gene 1, anti-proliferative

BTG1

3.3

1.1

3.0

6347

chemokine (C-C motif) ligand 2

CCL2

2.0

1.6

1.6

960

CD44 molecule (Indian blood group)

CD44

2.1

2.0

2.3

3491

cysteine-rich, angiogenic inducer, 61

CYR61

4.8

2.0

7.5

2014

epithelial membrane protein 3

EMP3

1.8

1.2

3.1

3589

interleukin 11

IL11

3.6

1.7

5.4

83729

inhibin, beta E

INHBE

2.1

3.0

1.9

182

jagged 1

JAG1

2.1

1.8

2.3

3976

leukemia inhibitory factor (cholinergic differentiation factor)

LIF

2.2

2.2

2.2

Apoptosis

56892

chromosome 8 open reading frame 4

C8orf4

1.2

1.2

2.3

8870

immediate early response 3

IER3

3.3

3.2

3.7

22822

pleckstrin homology-like domain, family A, member 1

PHLDA1

2.5

1.9

3.2

51330

tumor necrosis factor receptor superfamily, member 12A

TNFRSF12A

2.0

1.9

2.0

27242

tumor necrosis factor receptor superfamily, member 21

TNFRSF21

2.3

2.1

2.4

Cell adhesion/Cell-cell adhesion

6695

sparc/osteonectin, cwcv and kazal-like domains proteoglycan 1

SPOCK1

2.0

1.7

2.1

6696

secreted phosphoprotein 1

SPP1

1.9

2.5

2.1

Transport

3039

hemoglobin, alpha 1

HBA1

2.4

2.5

2.4

4884

neuronal pentraxin I

NPTX1

2.3

1.2

3.6

6507

solute carrier family 1, member 3

SLC1A3

1.8

2.0

1.8

6533

solute carrier family 6, member 6

SLC6A6

2.2

2.3

1.9

23657

solute carrier family 7, member 11

SLC7A11

2.3

2.4

1.8

Metabolic process

384

arginase, type II

ARG2

3.2

3.2

3.6

9945

glutamine-fructose-6-phosphate transaminase 2

GFPT2

2.0

2.0

1.9

9388

Lipase, endothelial

LIPG

1.9

1.4

2.1

7378

uridine phosphorylase 1

UPP1

2.1

1.8

2.0

Phosphorylation/Dephosphorylation

9201

doublecortin-like kinase 1

DCLK1

2.1

2.0

2.1

1843

dual specificity phosphatase 1

DUSP1

3.6

2.4

4.7

51207

dual specificity phosphatase 13

DUSP13

2.2

1.9

2.2

1846

dual specificity phosphatase 4

DUSP4

2.9

3.0

2.9

1847

dual specificity phosphatase 5

DUSP5

2.4

2.4

2.8

1848

dual specificity phosphatase 6

DUSP6

2.4

2.8

2.7

5578

protein kinase C, alpha

PRKCA

2.1

1.9

1.8

Response to stress

3337

DnaJ (Hsp40) homolog, subfamily B, member 1

DNAJB1

2.7

3.1

2.5

3303

heat shock 70 kDa protein 1A

HSPA1A

2.9

4.2

2.8

3310

heat shock 70 kDa protein 6

HSPA6

6.4

15.4

5.3

Others/Unknown

202

absent in melanoma 1

AIM1

1.7

1.8

2.1

23237

activity-regulated cytoskeleton-associated protein

ARC

2.5

2.3

2.3

1475

cystatin A (stefin A)

CSTA

4.6

5.3

5.4

56603

cytochrome P450, family 26, subfamily B, polypeptide 1

CYP26B1

2.1

1.7

2.1

23052

endonuclease domain containing 1

ENDOD1

2.0

2.1

2.1

2201

fibrillin 2

FBN2

2.1

1.6

1.8

10324

kelch repeat and BTB (POZ) domain containing 10

KBTBD10

3.0

1.9

2.4

5270

serpin peptidase inhibitor, clade E, member 2

SERPINE2

2.3

2.3

2.4

4071

transmembrane 4 L six family member 1

TM4SF1

1.9

1.8

2.3

25907

transmembrane protein 158 (gene/pseudogene)

TMEM158

2.1

2.4

2.5

7171

tropomysin 4

TPM4

2.5

1.5

3.5

7846

tubulin, alpha 1a

TUBA1A

1.9

2.1

1.8