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Table 2 Genes downregulated in the total RNA fraction in the presence of wild-type and mutant Tax proteins

From: Identification of bovine leukemia virus tax function associated with host cell transcription, signaling, stress response and immune response pathway by microarray-based gene expression analysis

Gene ID Gene description Gene Symbol Fold Change
    TaxWT TaxS240P TaxD247G
  Transcription/Translation/RNA processing     
23741 EP300 interacting inhibitor of differentiation 1 EID1 2.0 2.1 2.0
2625 GATA binding protein 3 GATA3 2.0 1.6 1.6
3398 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein ID2 1.6 1.4 2.2
23658 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) LSM5 1.7 1.8 2.0
63931 mitochondrial ribosomal protein S14 MRPS14 1.9 2.4 2.2
5936 RNA binding motif protein 4 RBM4 1.7 2.4 2.1
6591 snail homolog 2 (Drosophila) SNAI2 1.9 2.2 1.7
  Immune response/Response to virus     
23586 DEAD (Asp-Glu-Ala-Asp) box polypeptide 58 DDX58 2.9 3.3 3.9
79132 DEXH (Asp-Glu-X-His) box polypeptide 58 DHX58 2.1 2.2 2.3
10561 interferon-induced protein 44 IFI44 2.1 2.7 2.8
64135 interferon induced with helicase C domain 1 IFIH1 2.0 2.2 2.3
3434 interferon-induced protein with tetratricopeptide repeats 1 IFIT1 5.2 5.6 6.0
3433 interferon-induced protein with tetratricopeptide repeats 2 IFIT2 3.1 3.7 4.2
3437 interferon-induced protein with tetratricopeptide repeats 3 IFIT3 5.4 5.5 5.5
9636 ISG15 ubiquitin-like modifier ISG15 2.2 2.6 2.1
8638 2'-5'-oligoadenylate synthetase-like OASL 8.8 8.8 10.3
445347 TCR gamma alternate reading frame protein TARP 1.9 3.0 1.1
6967 T cell receptor gamma constant 2 TRGC2 2.1 3.4 1.2
56829 zinc finger CCCH-type, antiviral 1 ZC3HAV1 2.9 2.9 3.2
  Cell signalling     
3641 insulin-like 4 (placenta) INSL4 2.4 2.7 2.5
5122 proprotein convertase subtilisin/kexin type 1 PCSK1 2.8 2.8 2.5
25780 RAS guanyl releasing protein 3 (calcium and DAG-regulated) RASGRP3 1.6 2.1 1.8
  Nucleosome assembly     
94239 H2A histone family, member V H2AFV 1.9 2.0 1.9
8334 histone cluster 1, H2ac HIST1H2AC 2.1 2.0 2.0
8329 histone cluster 1, H2ag HIST1H2AG 1.6 2.2 1.7
8349 histone cluster 2, H2be HIST2H2BE 1.7 2.2 1.6
  Regulation of cell proliferation     
2247 fibroblast growth factor 2 (basic) FGF2 3.4 3.5 3.7
10216 proteoglycan 4 PRG4 1.7 2.2 1.7
5920 retinoic acid receptor responder (tazarotene induced) 3 RARRES3 2.3 2.4 2.5
  Apoptosis     
8743 tumor necrosis factor (ligand) superfamily, member 10 TNFSF10 2.5 2.9 2.6
  Cell cycle     
10083 Usher syndrome 1 C (autosomal recessive, severe) USH1C 2.0 2.0 1.7
  Transport     
57101 anoctamin 2 ANO2 1.9 2.1 2.0
6337 sodium channel, nonvoltage-gated 1 alpha SCNN1A 2.4 2.1 2.4
6717 sorcin SRI 2.3 2.3 2.6
  Ubiquitin     
51191 hect domain and RLD 5 HERC5 4.9 5.0 5.7
55008 hect domain and RLD 6 HERC6 2.2 2.5 2.2
  Others/Unknown     
83990 BRCA1 interacting protein C-terminal helicase 1 BRIP1 1.4 2.1 1.8
79940 chromosome 6 open reading frame 155 C6orf155 1.5 2.1 1.5
1601 disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila) DAB2 2.2 2.3 2.2
55601 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 DDX60 3.7 4.1 4.3
2335 fibronectin 1 FN1 2.0 2.5 1.8
23387 SIK family kinase 3 KIAA0999 1.2 1.2 2.2
54809 sterile alpha motif domain containing 9 SAMD9 1.8 2.0 2.4
6414 selenoprotein P, plasma, 1 SEPP1 2.1 2.1 2.2
8470 sorbin and SH3 domain containing 2 SORBS2 2.2 2.4 2.4