Table 2 Genes downregulated in the total RNA fraction in the presence of wild-type and mutant Tax proteins

Transcription/Translation/RNA processing

23741

EP300 interacting inhibitor of differentiation 1

EID1

2.0

2.1

2.0

2625

GATA binding protein 3

GATA3

2.0

1.6

1.6

3398

inhibitor of DNA binding 2, dominant negative helix-loop-helix protein

ID2

1.6

1.4

2.2

23658

LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae)

LSM5

1.7

1.8

2.0

63931

mitochondrial ribosomal protein S14

MRPS14

1.9

2.4

2.2

5936

RNA binding motif protein 4

RBM4

1.7

2.4

2.1

6591

snail homolog 2 (Drosophila)

SNAI2

1.9

2.2

1.7

Immune response/Response to virus

23586

DEAD (Asp-Glu-Ala-Asp) box polypeptide 58

DDX58

2.9

3.3

3.9

79132

DEXH (Asp-Glu-X-His) box polypeptide 58

DHX58

2.1

2.2

2.3

10561

interferon-induced protein 44

IFI44

2.1

2.7

2.8

64135

interferon induced with helicase C domain 1

IFIH1

2.0

2.2

2.3

3434

interferon-induced protein with tetratricopeptide repeats 1

IFIT1

5.2

5.6

6.0

3433

interferon-induced protein with tetratricopeptide repeats 2

IFIT2

3.1

3.7

4.2

3437

interferon-induced protein with tetratricopeptide repeats 3

IFIT3

5.4

5.5

5.5

9636

ISG15 ubiquitin-like modifier

ISG15

2.2

2.6

2.1

8638

2'-5'-oligoadenylate synthetase-like

OASL

8.8

8.8

10.3

445347

TCR gamma alternate reading frame protein

TARP

1.9

3.0

1.1

6967

T cell receptor gamma constant 2

TRGC2

2.1

3.4

1.2

56829

zinc finger CCCH-type, antiviral 1

ZC3HAV1

2.9

2.9

3.2

Cell signalling

3641

insulin-like 4 (placenta)

INSL4

2.4

2.7

2.5

5122

proprotein convertase subtilisin/kexin type 1

PCSK1

2.8

2.8

2.5

25780

RAS guanyl releasing protein 3 (calcium and DAG-regulated)

RASGRP3

1.6

2.1

1.8

Nucleosome assembly

94239

H2A histone family, member V

H2AFV

1.9

2.0

1.9

8334

histone cluster 1, H2ac

HIST1H2AC

2.1

2.0

2.0

8329

histone cluster 1, H2ag

HIST1H2AG

1.6

2.2

1.7

8349

histone cluster 2, H2be

HIST2H2BE

1.7

2.2

1.6

Regulation of cell proliferation

2247

fibroblast growth factor 2 (basic)

FGF2

3.4

3.5

3.7

10216

proteoglycan 4

PRG4

1.7

2.2

1.7

5920

retinoic acid receptor responder (tazarotene induced) 3

RARRES3

2.3

2.4

2.5

Apoptosis

8743

tumor necrosis factor (ligand) superfamily, member 10

TNFSF10

2.5

2.9

2.6

Cell cycle

10083

Usher syndrome 1 C (autosomal recessive, severe)

USH1C

2.0

2.0

1.7

Transport

57101

anoctamin 2

ANO2

1.9

2.1

2.0

6337

sodium channel, nonvoltage-gated 1 alpha

SCNN1A

2.4

2.1

2.4

6717

sorcin

SRI

2.3

2.3

2.6

Ubiquitin

51191

hect domain and RLD 5

HERC5

4.9

5.0

5.7

55008

hect domain and RLD 6

HERC6

2.2

2.5

2.2

Others/Unknown

83990

BRCA1 interacting protein C-terminal helicase 1

BRIP1

1.4

2.1

1.8

79940

chromosome 6 open reading frame 155

C6orf155

1.5

2.1

1.5

1601

disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)

DAB2

2.2

2.3

2.2

55601

DEAD (Asp-Glu-Ala-Asp) box polypeptide 60

DDX60

3.7

4.1

4.3

2335

fibronectin 1

FN1

2.0

2.5

1.8

23387

SIK family kinase 3

KIAA0999

1.2

1.2

2.2

54809

sterile alpha motif domain containing 9

SAMD9

1.8

2.0

2.4

6414

selenoprotein P, plasma, 1

SEPP1

2.1

2.1

2.2

8470

sorbin and SH3 domain containing 2

SORBS2

2.2

2.4

2.4