Table 3 Genes involved in signaling pathways regulated by wild-type and mutant Tax proteins (p < 0.05)*
Significant Pathway | TaxWT | TaxS240P | TaxD247G |
|---|---|---|---|
Direct p53 effectors | DUSP1, DUSP5, GDF15, HSPA1A, JUN, LIF | BDKRB2, DUSP1, DUSP5, GDF15, HSPA1A, JUN, LIF, SNAI2, SPP1 | DUSP1, DUSP5, GDF15, HSPA1A, JUN, LIF, SPP1 |
Validated transcriptional targets of AP1 family members Fra1 and Fra2 | FOS, FOSL1, GATA3, JUN, LIF, PLAUR | FOS, FOSL1, IL8, JUN, LIF | FOS, FOSL1, JUN, LIF |
IL1-mediated signaling events | DUSP1, FOS, FOSL1, GATA3, JUN | DUSP1, FOS, FOSL1, IL8, JUN | DUSP1, FOS, FOSL1, JUN |
BMP receptor signalling | DUSP1, FOS, FOSL1, GATA3, JUN | DUSP1, FOS, FOSL1, IL8, JUN | DUSP1, FOS, FOSL1, JUN |
p38 MAPK signaling pathway | DUSP1, FOS, FOSL1, GATA3, JUN | DUSP1, FOS, FOSL1, IL8, JUN | DUSP1, FOS, FOSL1, JUN |
Regulation of p38-alpha and p38-beta | DUSP1, FOS, FOSL1, GATA3, JUN | DUSP1, FOS, FOSL1, IL8, JUN | DUSP1, FOS, FOSL1, JUN |
IL12-mediated signaling events | ETV5, FOS, GATA3, JUN | ETV5, FOS, IL12A, JUN | ETV5, FOS, JUN |
Role of Calcineurin-dependent NFAT signaling in lymphocytes | FOS, FOSL1, GATA3, JUN | FOS, FOSL1, IL8, JUN | FOS, FOSL1, JUN |
Calcineurin-regulated NFAT-dependent transcription in lymphocytes | FOS, FOSL1, GATA3, JUN | FOS, FOSL1, IL8, JUN | FOS, FOSL1, JUN |
FOXM1 transcription factor network | ETV5, FOS, HSPA1A | ETV5, FOS, HSPA1A | ETV5, FOS, HSPA1A |
xef;ve CD4+ T cells | FOS, FOSL1, JUN | FOS, FOSL1, JUN | FOS, FOSL1, JUN |
CXCR4-mediated signaling events | FOS, FOSL1, JUN | FOS, FOSL1, JUN | FOS, FOSL1, JUN |
Glucocorticoid receptor signaling | FOS, GATA3, JUN | FOS, IL8, JUN | Â |
ATF-2 transcription factor network | DUSP1, DUSP5, JUN | DUSP1, DUSP5, IL8, JUN | DUSP1, DUSP5, HES1, JUN |
JNK signaling in the CD4+ TCR pathway | FOSL1, JUN | FOS, FOSL1, JUN | FOS, FOSL1, JUN |
Ras signaling in the CD4+ TCR pathway | FOS, FOSL1, JUN | FOS, FOSL1, JUN | FOS, FOSL1, JUN |
xef;ve CD8+ T cells | FOS, FOSL1, JUN | FOS, FOSL1, JUN | FOS, FOSL1, JUN |
Calcium signaling in the CD4+ TCR pathway | FOS, FOSL1, JUN | FOS, FOSL1, JUN | FOS, FOSL1, JUN |
Regulation of Wnt-mediated beta catenin signaling and target gene transcription | CYR61, JUN | IL8, JUN, SNAI2 | CYR61, ID2, JUN |
IL2-mediated signaling events | FOS, JUN | FOS, JUN | FOS, JUN |
ErbB2/ErbB3 signaling events | FOS JUN | FOS, JUN | FOS, JUN |
BCR signaling pathway | FOS, JUN | FOS, JUN | FOS, JUN |
IL12 signaling mediated by STAT4 | ETV5, JUN | ETV5, JUN | ETV5, JUN |
PDGFR-alpha signaling pathway | FOS, JUN | FOS, JUN | FOS, JUN |
Integrins in angiogenesis | CD44, FGF2 | CD44, FGF2, SPP1 | CD44, FGF2, SPP1 |
amb2 Integrin signalling | CYR61, PLAUR | Â | Â |