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Table 3 Genes involved in signaling pathways regulated by wild-type and mutant Tax proteins (p < 0.05)*

From: Identification of bovine leukemia virus tax function associated with host cell transcription, signaling, stress response and immune response pathway by microarray-based gene expression analysis

Significant Pathway TaxWT TaxS240P TaxD247G
Direct p53 effectors DUSP1, DUSP5, GDF15, HSPA1A, JUN, LIF BDKRB2, DUSP1, DUSP5, GDF15, HSPA1A, JUN, LIF, SNAI2, SPP1 DUSP1, DUSP5, GDF15, HSPA1A, JUN, LIF, SPP1
Validated transcriptional targets of AP1 family members Fra1 and Fra2 FOS, FOSL1, GATA3, JUN, LIF, PLAUR FOS, FOSL1, IL8, JUN, LIF FOS, FOSL1, JUN, LIF
IL1-mediated signaling events DUSP1, FOS, FOSL1, GATA3, JUN DUSP1, FOS, FOSL1, IL8, JUN DUSP1, FOS, FOSL1, JUN
BMP receptor signalling DUSP1, FOS, FOSL1, GATA3, JUN DUSP1, FOS, FOSL1, IL8, JUN DUSP1, FOS, FOSL1, JUN
p38 MAPK signaling pathway DUSP1, FOS, FOSL1, GATA3, JUN DUSP1, FOS, FOSL1, IL8, JUN DUSP1, FOS, FOSL1, JUN
Regulation of p38-alpha and p38-beta DUSP1, FOS, FOSL1, GATA3, JUN DUSP1, FOS, FOSL1, IL8, JUN DUSP1, FOS, FOSL1, JUN
IL12-mediated signaling events ETV5, FOS, GATA3, JUN ETV5, FOS, IL12A, JUN ETV5, FOS, JUN
Role of Calcineurin-dependent NFAT signaling in lymphocytes FOS, FOSL1, GATA3, JUN FOS, FOSL1, IL8, JUN FOS, FOSL1, JUN
Calcineurin-regulated NFAT-dependent transcription in lymphocytes FOS, FOSL1, GATA3, JUN FOS, FOSL1, IL8, JUN FOS, FOSL1, JUN
FOXM1 transcription factor network ETV5, FOS, HSPA1A ETV5, FOS, HSPA1A ETV5, FOS, HSPA1A
xef;ve CD4+ T cells FOS, FOSL1, JUN FOS, FOSL1, JUN FOS, FOSL1, JUN
CXCR4-mediated signaling events FOS, FOSL1, JUN FOS, FOSL1, JUN FOS, FOSL1, JUN
Glucocorticoid receptor signaling FOS, GATA3, JUN FOS, IL8, JUN  
ATF-2 transcription factor network DUSP1, DUSP5, JUN DUSP1, DUSP5, IL8, JUN DUSP1, DUSP5, HES1, JUN
JNK signaling in the CD4+ TCR pathway FOSL1, JUN FOS, FOSL1, JUN FOS, FOSL1, JUN
Ras signaling in the CD4+ TCR pathway FOS, FOSL1, JUN FOS, FOSL1, JUN FOS, FOSL1, JUN
xef;ve CD8+ T cells FOS, FOSL1, JUN FOS, FOSL1, JUN FOS, FOSL1, JUN
Calcium signaling in the CD4+ TCR pathway FOS, FOSL1, JUN FOS, FOSL1, JUN FOS, FOSL1, JUN
Regulation of Wnt-mediated beta catenin signaling and target gene transcription CYR61, JUN IL8, JUN, SNAI2 CYR61, ID2, JUN
IL2-mediated signaling events FOS, JUN FOS, JUN FOS, JUN
ErbB2/ErbB3 signaling events FOS JUN FOS, JUN FOS, JUN
BCR signaling pathway FOS, JUN FOS, JUN FOS, JUN
IL12 signaling mediated by STAT4 ETV5, JUN ETV5, JUN ETV5, JUN
PDGFR-alpha signaling pathway FOS, JUN FOS, JUN FOS, JUN
Integrins in angiogenesis CD44, FGF2 CD44, FGF2, SPP1 CD44, FGF2, SPP1
amb2 Integrin signalling CYR61, PLAUR   
  1. *Up- or downregulated genes are represented by regular or italic characters, respectively.