Conserved amino acid motifs within CIR sequences. Amino acid motifs present within the CIR repertoire were identified by MEME analysis (Bailey and Elkan, 1994). These are shown as Weblogo images , A). Hydrophobic residues are shown in blue, polar, non-charged residues in green, acidic residues in pink and positively charged residues in red. E-values refer to the significance of each motif found within the CIR sequences. The frequency (percentage) of CIR sequences within the whole repertoire, clade A1 or whole sub-families A and B containing each motif is shown. Examples of motif arrangement in CIR proteins are shown, B), using PCHAS_040110 and PCHAS_070130, which belong to the sub-families A (clade A1) and B, respectively. Exon: exon boundaries in the encoding cir genes are indicated by dotted lines.