Table 3 Ortholog analysis and classifications of the putative TCS proteins
| Â | TCSProtein | RR family | C1 | C2 | S. mutans UA159 | S. mutans NN2025 | S. mutans 5 DC8 | S. mutans KK21 | S. mutans KK23 | S.mutans AC4446 | S. mutans ATCC 25175 | S. mutans NCTC 11060 | S.ratti DSM20564 | S. sobrinus DSM20742 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
TCS-1 | HK (VicK) | - | HPK1 | C | SMU.1516 | GI|290580114 | smc|01510 | smd|01560 | sme|01514 | smf|01497 | smg|01519 | smh|01557 | sra|1000270(90) | sob|6900029(74) |
| Â | RR (VicR) | OmpR | - | Â | SMU.1517 | GI|290580113 | smc|01511 | smd|01561 | sme|01515 | smf|01498 | smg|01520 | smh|01558 | sra|1000269(96) | sob|6900028(87) |
TCS-2 | HK (CiaH) | - | HPK1 | E | SMU.1128 | GI|290580439 | smc|01121 | smd|01170 | sme|01262 | smf|01137 | smg|01147 | smh|01166 | sra|3300059(83) | sob|10000005(53) |
| Â | RR (CiaR) | OmpR | - | Â | SMU.1129 | GI|290580438 | smc|01122 | smd|01171 | sme|01263 | smf|01138 | smg|01148 | smh|01167 | sra|3300058(94) | sob|10000006(86) |
TCS-3 | HK (CovS) | - | HPK1 | E | SMU.1145c | GI|290580424 | smc|01138 | smd|01187 | sme|01279 | smf|01154 | smg|01163 | smh|01183 | sra|3300038(48) | Absent |
| Â | RR (CovR) | OmpR | - | Â | SMU.1146c | GI|290580423 | smc|01139 | smd|01188 | sme|01280 | smf|01155 | smg|01164 | smh|01184 | sra|3300037(76) | Absent |
TCS-4 | HK (KinF) | - | HPK1 | E | SMU.928 | GI|290580625 | smc|00919 | smd|00964 | sme|01045 | smf|00943 | smg|00948 | smh|00938 | sra|1200002(75) | sob|15200007(50) |
| Â | RR (LlrF) | OmpR | - | Â | SMU.927 | GI|290580626 | smc|00918 | smd|00963 | sme|01044 | smf|00942 | smg|00947 | smh|00937 | sra|1200003(89) | sob|15200008(70) |
TCS-5 | HK (ScnK) | - | HPK1 | E | SMU.1814 | GI|290579846 | smc|01808 | smd|01870 | sme|01810 | smf|01679 | Absent | Absent | Absent | Absent |
| Â | RR (ScnR) | OmpR | - | Â | SMU.1815 | GI|290579845 | smc|01809 | smd|01871 | sme|01811 | smf|01680 | Absent | Absent | Absent | Absent |
TCS-6 | HK (SpaK) | - | HPK1 | E | SMU.660 | GI|290580857 | smc|00645 | smd|00684 | sme|00777 | smf|00640 | smg|00672 | smh|00668 | sra|1000132(71) | sob|3600002(47) |
| Â | RR (SpaR) | OmpR | - | Â | SMU.659 | GI|290580858 | smc|00643 | smd|00682 | sme|00775 | smf|00639 | smg|00670 | smh|00666 | sra|1000130(80) | sob|3600003(67) |
TCS-7 | HK (PhoR) | - | HPK1 | E | SMU.1037c | GI|290580522 | smc|01032 | smd|01081 | sme|01153 | smf|01049 | smg|01055 | smh|01052 | Absent | Absent |
| Â | RR (YcbL) | OmpR | - | Â | SMU.1038c | GI|290580521 | smc|01033 | smd|01082 | sme|01154 | smf|01050 | smg|01056 | smh|01053 | Absent | Absent |
TCS-8 | HK (KinG) | - | HPK1 | M | SMU.1009 | GI|290580539 | smc|01005 | smd|01053 | sme|01135 | smf|01030 | smg|01036 | smh|01024 | sra|900051(80) | sob|6900007(55) |
| Â | RR (LlrG) | OmpR | - | Â | SMU.1008 | GI|290580540 | smc|01004 | smd|01052 | sme|01134 | smf|01029 | smg|01035 | smh|01023 | sra|900049(89) | sob|6900006(64) |
TCS-9 | HK (LevS) | - | HPK7 | M | SMU.1965c | GI|290579718 | smc|01957 | smd|02016 | sme|01953 | smf|01824 | smg|01946 | smh|01994 | sra|3500035(88) | Absent |
| Â | RR (LevR) | NarL | - | Â | SMU.1964c | GI|290579719 | smc|01956 | smd|02015 | sme|01952 | smf|01823 | smg|01945 | smh|01993 | sra|3500036(91) | Absent |
TCS-10 | HK (LytS) | - | HPK8 | M | SMU.577 | GI|290580924 | smc|00560 | smd|00598 | sme|00685 | smf|00568 | smg|00588 | smh|00583 | sra|1000030(95) | sob|800016(80) |
| Â | RR (LytT) | LytTR | - | Â | SMU.576 | GI|290580925 | smc|00559 | smd|00597 | sme|00684 | smf|00567 | smg|00587 | smh|00582 | sra|1000029(92) | sob|800017(70) |
TCS-11 | HK (LiaS) | - | HPK7 | M | SMU.486 | GI|290581011 | smc|00465 | smd|00505 | sme|00595 | smf|00473 | smg|00493 | smh|00475 | sra|2900015(89) | sob|4200072(64) |
| Â | RR (LiaR) | NarL | - | Â | SMU.487 | GI|290581010 | smc|00466 | smd|00506 | sme|00596 | smf|00474 | smg|00494 | smh|00476 | sra|2900013(92) | sob|4200071(82) |
TCS-12 | HK (HK11) | - | HPK7 | M | SMU.1548c | GI|290580085 | smc|01542 | smd|01591 | sme|01547 | smf|01527 | smg|01550 | smh|01590 | sra|1000231(53) | sob|11300005(50) |
| Â | RR (RR11) | NarL | - | Â | SMU.1547c | GI|290580086 | smc|01541 | smd|01590 | sme|01545 | smf|01526 | smg|01548 | smh|01588 | sra|1000232(82) | sob|11300004(72) |
TCS-13 | HK(ComD) | - | HPK10 | M | SMU.1916 | GI|290579761 | smc|01910 | smd|01968 | sme|01906 | smf|01777 | smg|01900 | smh|01947 | Absent | sob|8500005(37) |
| Â | RR (ComE) | LytTR | - | Â | SMU.1917 | GI|290579760 | smc|01911 | smd|01969 | sme|01907 | smf|01778 | smg|01901 | smh|01948 | Absent | sob|8500004(43) |
TCS-14 | HK | - | ? | C | SMU.45 | GI|290579565 | smc|00046 | smd|00053 | sme|00049 | Absent | Absent | Absent | Absent | Absent |
| Â | RR | ? | - | Â | SMU.46 | GI|290579566 | smc|00047 | smd|00054 | sme|00050 | Absent | Absent | Absent | Absent | Absent |
TCS-15 | HK(ComP) | - | HPK7 | M | Absent | Absent | Absent | Absent | Absent | Absent | Absent | smh|00177 | Absent | Absent |
| Â | RR(CmpR) | NarL | - | Â | Absent | Absent | Absent | Absent | Absent | Absent | Absent | smh|00178 | Absent | Absent |
TCS-16 | HK | Â | HPK1 | E | Absent | Absent | Absent | Absent | Absent | Absent | Absent | Absent | sra|800020 | Absent |
| Â | RR | OmpR | Â | Â | Absent | Absent | Absent | Absent | Absent | Absent | Absent | Absent | sra|800019 | Absent |
TCS-17 | HK | Â | HPK1 | E | Absent | Absent | Absent | Absent | Absent | Absent | Absent | Absent | sra|3500015 | Absent |
| Â | RR | OmpR | Â | Â | Absent | Absent | Absent | Absent | Absent | Absent | Absent | Absent | sra|3500014 | Absent |
TCS-18 | HK | Â | HPK11 | C | Absent | Absent | Absent | Absent | Absent | Absent | Absent | Absent | sra|1400052 | Absent |
| Â | RR | AmiR | Â | Â | Absent | Absent | Absent | Absent | Absent | Absent | Absent | Absent | sra|1400053 | Absent |
Orphan HK1 | HK | Â | HPK1 | N | Absent | Absent | Absent | Absent | Absent | Absent | Absent | Absent | sra|3800008 | Absent |
Orphan HK2 | HK | Â | ? | M | Absent | Absent | Absent | Absent | Absent | Absent | Absent | Absent | Absent | sob|13200014 |
Orphan RR1 | RR (GcrR) | OmpR | - | Â | SMU.1924 | GI|290579753 | smc|01920 | smd|01978 | sme|01916 | smf|01787 | smg|01910 | smh|01957 | sra|200007(87) | sob|100018(55) |
Orphan RR2 | Â | LytTR | Â | Â | Absent | Absent | Absent | Absent | Absent | Absent | Absent | Absent | Absent | sob|14100005 |