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Table 4 A brief summary of known/putative functions of the TCSs identified in S. mutans UA159

From: A genome-wide study of two-component signal transduction systems in eight newly sequenced mutans streptococci strains

TCS
Cluster
TCS protein GenBank
Locus Tag
Functions References
TCS-1 HK-VicK
RR-VicR
SMU.1516
SMU.1517
Biofilm development, competence development, oxidative stress tolerance, acid tolerance, autolysin production, glucan metabolism, fructan metabolism. [7, 8, 10, 24, 40, 42, 43]
TCS-2 HK-CiaH
RR-CiaR
SMU.1128
SMU.1129
Sucrose-dependent biofilm formation, competence development, multiple stress response, bacteriocin production [12, 44, 45]
TCS-3 HK-CovS
RR-CovR
SMU.1145
SMU.1146
Acid tolerance, hydrogen peroxide resistance, murine macrophage killing. [12, 46]
TCS-4 HK-KinF
RR-LlrF
SMU.928
SMU.927
Acid tolerance, pp(G)pp metabolism, control of alarmone synthesis. [47, 48]
TCS-5 HK- ScnK
RR- ScnR
SMU.1814
SMU.1815
Bacteriocin production*. [49]*
TCS-6 HK- SpaK
RR- SpaR
SMU.660
SMU.659
Bacteriocin production*, self-protection against anti-microbial peptides*. [5052]*
TCS-7 HK- PhoR
RR-YcbL
SMU.1037
SMU.1038
Unknown.  
TCS-8 HK-KinG
RR-LlrG
SMU.1009
SMU.1008
Bacteriocin resistance, substrate transport in cell envelope stress. [53, 54]
TCS-9 HK-LevS
RR-LevR
SMU.1965
SMU.1964
Biofilm formation, acid tolerance, fructan metabolism. [55, 56]
TCS-10 HK-LytS
RR-LytT
SMU.577
SMU.576
Biofilm formation, oxidative stress tolerance, autolysis, fructan metabolism, cell wall metabolism*. [57]*, [48, 58]
TCS-11 HK-LiaS
RR-LiaR
SMU.486
SMU.487
Biofilm formation, acid tolerance, cell envelope stress response, bacteriocin production, bacteriocin resistance, sucrose-dependent adherence. [37, 5962]
TCS-12 HK-HK11
RR-RR11
SMU.1548
SMU.1547
Unknown.  
TCS-13 HK-ComD
RR-ComE
SMU.1916
SMU.1917
Biofilm formation, quorum sensing, competence development, bacteriocin production. [9, 44, 6365]
TCS-14 HK
RR
SMU.45
SMU.46
Unknown.  
Orhpan RR1 RR-GcrR SMU.1924 Sucrose-dependent adherence, glucan metabolism, pH homeostasis, competence development. [6672]
  1. In case no knowledge is available on the functions of some TCSs in UA159, reports on homologous TCSs in other microorganisms, preferably Streptococcus species (highlighted by the astral sign*) are provided.