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Table 10 List of genes with altered expression according to microarray analysis related to KEGG lysosome pathway

From: Gene expression analysis of Drosophilaa Manf mutants reveals perturbations in membrane traffic and major metabolic changes

KEGG

Gene

embryo

larvae

 

name

name

o.ex.

mut.

o.ex.

mut.

Description

AGA

CG10474

 

down

 

down

N4-(beta-N-acetylglucosaminyl)-L-asparaginase

SGSH

CG14291

  

up

down

N-sulfoglucosamine sulfohydrolase

AP-3

cm

  

up

down

carmine

ARS

CG7402

 

down

down

down

arylsulfatase B

ATPeV

CG7678

 

down

up

down

V-type H+-transporting ATPase subunit I

ATPeV

Vha100-1

up

down

  

Vha100-1

ATPeV

VhaSFD

 

down

  

Vacuolar H[+]-ATPase SFD subunit

cystinosin

CG17119

up

down

  

cystinosin

GUSB

CG2135

up

down

  

beta-glucuronidase

cathepsin

cathD

 

down

  

cathepsin D, pepsin A

LAMAN

CG6206

up

down

  

lysosomal alpha-mannosidase

CLN3

cln3

 

down

  

cln3

GLA

CG7997

 

down

  

alpha-galactosidase

ATPeV

Vha16

  

down

up

Vacuolar H[+] ATPase 16kD subunit

LYPLA3

CG31683

 

down

down

up

lysophospholipase III

CLN1

Ppt2

up

down

down

up

Palmitoyl-protein thioesterase 2

LAMAN

CG5322

up

down

down

up

lysosomal alpha-mannosidase

LYMP

trpml

 

down

down

up

control of membrane trafficking of proteins and lipids

NAGA

CG5731

up

down

up

up

alpha-N-acetylgalactosaminidase

LIMP

Tsp39D

  

down

up

Tetraspanin 39D

LIMP

Tsp29Fa

  

down

up

Tetraspanin 29Fa

HGSNAT

CG6903

  

down

up

heparan-alpha-glucosaminide N-acetyltransferase

saposin

Sap-r

  

down

up

Saposin-related

cathepsin

cathF

  

down

up

cathepsin F

LAMAN

CG9466

  

down

up

lysosomal alpha-mannosidase

LAMAN

CG9463

  

down

up

lysosomal alpha-mannosidase

AP-3

g

down

up

  

garnet, adaptor-related protein complex 3

clathrin

Chc

down

up

  

Clathrin heavy chain

GLB

CG9092

up

up

up

up

beta galactosidase

GTPase

Gie

   

up

N-terminally acetylated Arf-like GTPase

LAMAN

CG9465

   

up

lysosomal alpha-mannosidase

GBA

CG31148

up

up

 

up

glucosylceramidase

cathepsin

cathL

up

up

  

cathepsin L

GNS

CG18278

up

up

  

N-acetylglucosamine-6-sulfatase

GGA

Gga

up

up

  

Gga

AP-1

AP-1s

up

up

  

AP-1sigma

cathepsin

Cp1

up

up

  

Cysteine proteinase-1

LYMP

spin

up

up

  

spinster, lysosomal turnover regulator

GNS

CG30059

  

up

 

N-acetylglucosamine-6-sulfatase

  1. Significant alterations in gene expression from wild type are shown by word code; "up" represents upregulation and "down" downregulation of gene expression. ID stands for the particular homologue gene name in Drosophila. Notice that the same KEGG identifier can lead to several different genes. The according coloured scheme for lysosome KEGG pathway is presented in Additional File 9.