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Table 11 List of genes with altered expression according to microarray analysis related to KEGG pathway of Parkinson's disease

From: Gene expression analysis of Drosophilaa Manf mutants reveals perturbations in membrane traffic and major metabolic changes

KEGG

Human

embryo

larvae

Flybase

 

name

gene

o.ex.

mut.

o.ex.

mut.

ID

Description

TH

TH

 

up

  

CG10118

pale, tyrosine hydroxylase

VMAT

VMAT

   

up

CG6139

vesicular monoamine transporter

DAT

SCL6A3

up

down

  

CG8380

dopamine transporter

HTRA2

HTRA2

up

down

  

CG8464

HtrA serine peptidase 2

NDUFV1

NDUFV1

up

down

  

CG9140

NADH dehydrogenase

SNCAIP

SNCAIP

  

up

down

CG5424

forked, actin binding α synuclein interacting

CDCREL1

PNUTL1

  

up

down

CG7238

septin interacting protein 1

CytC

CYCS

  

up

down

CG14235

cytochrome-c oxidase

UQCRH

UQCRH

up

 

up

down

CG30354

ubiquinol-cytochrome-c reductase

 

SIP2

  

up

down

CG9188

septin interacting protein 2

 

SLC25A6

  

up

down

CG1683

mitochondrial adenine nucleotide translocase 2

Uchl1

UCHL

  

up

 

CG4265

Ubiquitin carboxy-terminal hydrolase

mPTP

VDAC2

up

up

up

down

CG17137

Porin2, voltage-gated anion channel

ATPase

ATP5EP2

  

up

 

CG31477

mitochondrial ATPase ε subunit, F1 complex

NDUFA2

NDUFA2

  

up

up

CG15434

NADH dehydrogenase

 

SEP4

 

up

 

up

CG9699

Septin 4

Ube2J2

UBE2J2

  

down

up

CG5823

ubiquitin-protein ligase

NDUFV2

NDUFV2

   

up

CG5707

NADH dehydrogenase

 

UBE2H

   

up

CG2257

Ubc-E2H, ubiquitin-protein ligase

Ube2L3

UBE2L3

  

down

down

CG12799

Ubiquitin conjugating enzyme 84D

 

UBQLN1

  

down

 

CG14224

EF1B ubiquitin-assoc. translation elongation factor

Ubh4

UCHL

   

down

CG3431

Ubiquitin C-terminal hydrolase

 

USP36

   

down

CG5505

scrawny, ubiquitin protease

 

SIP3

   

down

CG1937

septin interacting protein 3

Uba1

UBA1

 

up

  

CG1782

ubiquitin activating enzyme 1

CytC

CYCS

up

up

  

CG2249

cytochrome-c oxidase

 

SEP1

 

up

  

CG1403

Septin-1

 

UBE2E2

 

up

  

CG6720

Ubiquitin conjugating enzyme 2

DJ-1

DJ-1

 

down

  

CG6646

DJ-1α

CytC

CYCS

 

down

  

CG13263

cytochrome c distal

CytC

CYCS

 

down

  

CG14028

cyclope, cytochrome-c oxidase

CytC

CYC1

 

down

  

CG4769

electron transporter

ATPase

ATP5G2

down

down

  

CG1746

hydrogen-exporting ATPase

ATPase

ATP5E

 

down

  

CG9032

stunted, hydrogen-exporting ATPase

  1. Significant alterations in gene expression from wild type are shown by word code; "up" represents upregulation and "down" downregulation of gene expression. Notice that the same KEGG identifier can lead to several different genes. Several Drosophila genes associated with processes in PD missing from KEGG pathway were added. The according coloured scheme for Parkinson's disease KEGG pathway is presented in Figure 5.