Gene expression analysis of Drosophilaa Manf mutants reveals perturbations in membrane traffic and major metabolic changes

Table 4 GO clustering analysis of downregulated genes in Manf^mzΔ96 mutants

	GO term	enrichment score	gene number
1	membrane transporters	2.9	25
2	transmembrane proteins	2.3	146
3	amine catabolic processes	2.1	11
4	mitochondrion	2.0	28
...	DNA replication, DNA metabolic process	1.7	26
...	pyrimidine metabolism	1.5	15
...	ncRNA, rRNA metabolic process, ribosome biogenesis	1.4	23
...	structural constituent of chitin-based cuticle	1.4	14
...	Hox, DNA dependent transcription regulation	1.3	122
...	organophosphate, glycerolipid metabolic process	1.3	18
...	neurological system process	1.0	44

Clusters are represented starting from the highest enrichment score in diminishing order. Only the highest clusters are shown, for the full list of DAVID cluster analysis of downregulated genes in Manf^mzΔ96 mutants, see Additional file 2. In the case of missing order number replaced by "..." there were several clusters higher in order describing similar processes that have been listed already above.

ISSN: 1471-2164