Table 7 List of genes with altered expression according to microarray analysis related to KEGG pathway of protein processing in ER

NEF

CG10420

down

up

down

up

SIL1, BiP-associated protein, mutated in MSS

Hsp90

hsp83

up

down

down

Heat shock protein 83

PERK

pek

up

down

down

PEK; pancreatic eIF-2alpha kinase, UPR sensor

Hrd1

sip3

up

down

down

septin interacting protein 3, ERAD

DSK2

ubiqn

up

down

down

ubiquilin, ubiquitin-ass./transl. elongation factor EF1B

Cul1

lin19

down

up

up

lin-19-like, ubiquitin protein ligase, cullin homology

Skp1

skpC

down

up

down

skpC, E3 ubiquitin ligase

EDEM

Edem1

up

down

Edem1, Glycoside hydrolase

Ubx

p47

down

down

p47, human NSFL1

Skp1

skpE

down

down

RNA polymerase II transcription elongation factor

Sec23/24

CG1472

down

down

COP complex II, mediator of selective export from ER

UGGT

CG6850

down

UDP-glucose-glycoprotein glucosyltransferase

DOA10

CG1317

down

E3 ubiquitin-protein ligase MARCH6

Sec13/31

CG6773

up

up

up

involved in export from ER, nuclear import, cuticle development

MKK7

CG4353

up

up

hemipterous, Jun kinase kinase

Hsp70

Hspc1

up

Heat shock protein cognate 1

Ubc6/7

CG5823

up

ubiquitin-conjugating enzyme E2 J2

Hsp40

dnajh

up

DnaJ homolog subfamily B member 11

NEF

CG10973

up

hsp70-interacting protein

Bap31

CG13887

up

B-cell receptor-associated protein 31

NEF

CG2918

up

hypoxia up-regulated 1

sHSF

l(2)efl

up

lethal (2) essential for life

IRE-1

ire-1

up

inositol requiring enzyme 1, Ser/Thr kinase, UPR sensor

Hsp70

Hsp68

up

Heat shock protein 68

UbcH5

Ubce2

up

Ubiquitin conjugating enzyme 2

Hsp70

Hspc2

up

Heat shock protein cognate 2

NEF

CG7945

up

BCL2-associated athanogene 2

Sec13/31

CG8266

up

COP II complex, secretory vesicle budding from ER

S2P

S2P

up

endopeptidase