Gene expression analysis of Drosophilaa Manf mutants reveals perturbations in membrane traffic and major metabolic changes

Table 8 List of genes with altered expression according to microarray analysis related to KEGG pathway of exocytosis and SNARE complexes

KEGG		embryo		larvae
name	gene	o.ex.	mut.	o.ex.	mut.	description
Bos	CG4780	up	up	up	down	membrin
Vti1	koko			up	down	kokopelli; cyclin-dependent protein kinase regulator
SNAP29	usnp	up	down		down	usnp; ubisnap
Stx6	Syx 6	up	down			Syntaxin 6
	Syt7		down	down	down	calcium-dependent phospholipid binding, Synaptotagmin.
Stx1-4	Syx 1A			down	down	Syntaxin 1A
Stx17	Syx 17			down	up	synaptic vesicle docking; neurotransmitter secretion
	Synd		up		up	neurotransmitter secretion; synaptic vesicle endocytosis
Stx13	Syx 13		up			SNAP receptor: cytokinesis after mitosis and meiosis
	Syb	up	up			SNAP receptor: synaptic vesicle docking in exocytosis
Syx18	Syx 18	up	up			Syntaxin 18
Bet1	CG14084	up	up			Bet1
VAMP7	CG1599	up	up			vesicle-associated membrane protein 7

Significant alterations in gene expression from wild type are shown by word code; "up" represents upregulation and "down" downregulation of gene expression. Gene name stands for the particular homologue gene name in Drosophila. Few related Drosophila genes associated with neurotransmission missing from KEGG pathway were added. The according coloured scheme for exocytosis and SNARE of KEGG pathway is presented in Additional File 8. p.res = paternal rescue, mut = mutant, o.ex. = overexpression.

ISSN: 1471-2164