Figure 2

PCA analysis based on the complete transciptional data set visualizing the tridimentsional distribution of cell lines (CM, pink) compared to pair melanoma tumors (TM, yellow) (A) of the distribution of the samples according to the patient identity from which either TMs or CMs were derived (B). (C) Venn diagram displaying the results of a Pearson's correlation analysis of gene expression between TMs and CMs (p-value cutoff < 0.05). (D) Self-organizing hierarchical tree based on the top 1,006 genes whose expression was most significantly (p-value < 0.01) correlated between TMs light green) and CMs (light pink); sample ID refers to the patients from which either a TM or CM was derived. Brackets underline autologous TM/CM pairs demonstrating a comparable expression pattern. (E) Top functional network generated by Ingenuity Pathway Analysis (IPA) www.ingenuity.com based on the 3,030 target genes. (F) Bar graph demonstrating the top biological functions of the 3,030 target genes according to IPA.