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Table 2 Natrialba magadii ATCC 43099 genes involved in the biosynthesis of various vitamins and siroheme

From: A comparative genomics perspective on the genetic content of the alkaliphilic haloarchaeon Natrialba magadii ATCC 43099T

Locus tag, Protein, pI, (Asp + Glu)/ (Arg + Lys)

Annotation

Closest homolog (locus tag, protein, identity)

Thiamine

Nmag_0434, 309 aa, 4.31, 55/25

HTH domain protein/thiamine-phosphate synthase (ThiN)

Htur_2542, 307 aa, 81%

Nmag_0460, 387 aa, 3.72, 92/17

ABC-type thiamine transporter substrate-binding protein (ThiB)

Htur_2516, 370 aa, 68%

Nmag_0461, 663 aa, 4.87, 50/34

ABC-type thiamine transporter permease protein (ThiP)

Htur_2515, 634 aa, 84%

Nmag_0462, 363 aa, 4.58, 55/29

ABC-type thiamine transporter ATPase protein (ThiQ)

Htur_2514, 405 aa, 68%

Nmag_0567, 88 aa, 4.48, 18/8

MoaD family protein (MoaD)

HacjB3_04780, 90 aa, 55%

Nmag_0869, 219 aa, 4.50, 42/16

Thiamine biosynthesis/salvage protein (TenA)

Htur_2707, 219 aa, 85%

Nmag_1281, 345 aa, 4.16, 62/19

Aminoimidazole ribotide synthase related protein (PurM)

Htur_3233, 346 aa, 77%

Nmag_1282, 461 aa, 4.33, 76/33

Phosphomethylpyrimidine kinase/thiamine-phosphate synthase (ThiDN)

Htur_3232, 453 aa, 79%

Nmag_1394, 278 aa, 4.25, 50/21

SAMP-activating enzyme E1 (UbaA)

Htur_3268, 280 aa, 86%

Nmag_1515, 295 aa, 4.17, 54/18

Thiamine-monophosphate kinase (ThiL)

Htur_3484, 307 aa, 71%

Nmag_1810, 280 aa, 4.04, 49/14

Hydroxyethylthiazole kinase (ThiM)

Htur_0247, 279 aa,75%

Nmag_1811, 221 aa, 4.33, 35/15

Thiamine-phosphate synthase (ThiE)

Htur_0246, 222 aa, 76%

Nmag_1914, 87 aa, 4.49, 19/10

MoaD family protein (MoaD)

Htur_0025, 78 aa, 72%

Nmag_1940, 383 aa, 3.94, 85/23

ABC-type thiamine transporter substrate-binding protein (ThiB)

Halxa_1431, 376 aa, 53%

Nmag_2413, 299 aa, 4.28, 55/21

HTH domain protein/thiamine-phosphate synthase (ThiN)

Htur_1469, 299 aa, 85%

Nmag_2419, 309 aa, 4.31, 54/22

THI4-related putative thiazole biosynthesis enzyme

Htur_1462, 310 aa, 93%

Nmag_2593, 503 aa, 4.37, 98/39

Hydroxymethylpyrimidinephosphate synthase (ThiC)

Htur_1332, 480 aa, 88%

Nmag_2668, 111 aa, 4.09, 21/8

MoaD family protein (MoaD)

Htur_0699, 96 aa, 78%

Nmag_2971, 94 aa, 3.91, 24/6

MoaD family protein (MoaD)

Htur_0580, 93 aa, 85%

Nmag_3460, 392 aa, 4.60, 68/ 38

Thiamine/thiouridine biosynthesis protein (ThiI)

Htur_1671, 392 aa, 78%

Nmag_3812, 278 aa, 4.45, 45/23

SAMP-activating enzyme E1 (UbaA)

Hlac_0421, 270 aa, 55%

Riboflavin

Nmag_0941, 235 aa, 4.45, 50/22

CTP-dependent riboflavin kinase (RibK)

Htur_2982, 235 aa, 87%

Nmag_0942, 243 aa, 4.29, 45/14

3,4-dihydroxy-2-butanone 4-phosphate synthase (RibB)

Htur_2983, 243 aa, 75%

Nmag_1403, 208 aa, 4.25, 43/16

Riboflavin synthase (RibE)

Htur_3261, 201 aa, 83%

Nmag_3078, 220 aa, 4.42, 42/22

2,5-diamino-6-(ribosylamino)-4(3H)-pyrimidinone 5'-phosphate reductase (RibG)

Htur_5200, 220 aa, 78%

Nmag_3262, 143 aa, 4.08, 25/9

6,7-dimethyl-8-ribityllumazine synthase (RibH)

Htur_1120, 152 aa, 83%

Nmag_3329, 254 aa, 4.44, 44/18

GTP cyclohydrolase III (Gch3)

Htur_1598, 253 aa, 86%

NAD

Nmag_1544, 332 aa, 4.82, 55/39

NAD(+) synthase (NadE)

Htur_3513, 302 aa, 65%

Nmag_2475, 284 aa, 4.26, 55/21

NAD(+) synthase (NadE)

Hbor_04860, 277 aa, 56%

Nmag_2823, 172 aa, 4.46, 28/13

Nicotinamide-nucleotide adenylyltransferase (NadM)

Htur_0861, 172 aa, 90%

Nmag_2846, 264 aa, 4.53,46/19

NAD(+) synthase (NadE)

Halxa_1654, 264 aa, 82%

Nmag_2920, 300 aa, 4.84, 48/30

Nicotinate-nucleotide pyrophosphorylase (NadC)

Halxa_1866, 271 aa, 78%

Nmag_2921, 531 aa, 4.42, 101/47

L-aspartate oxidase (NadB)

Htur_0529, 532 aa, 81%

Nmag_2922, 377 aa, 4.21, 80/26

Quinolinate synthase A (NadA)

Htur_0530, 377 aa, 89%

Coenzyme F420

  

Nmag_0541, 341 aa, 4.27, 67/32

Probable F420-dependent oxidoreductase

Htur_1978, 357 aa, 78%

Nmag_0613, 330 aa, 4.00, 55/16

LPPG:FO 2-phospho-L-lactate transferase (CofD)

Halxa_2708, 330 aa, 85%

Nmag_1056, 336 aa, 4.28, 63/27

Probable F420-dependent oxidoreductase

Htur_2908, 333 aa, 84%

Nmag_1142, 318 aa, 4.15, 59/13

Probable F420-dependent oxidoreductase

Halxa_4117, 318 aa, 75%

Nmag_1562, 222 aa, 4.30, 43/16

F420H2:NADP+ oxidoreductase ( NpdG)

Htur_3495, 222 aa, 84%

Nmag_1581, 260 aa, 4.22, 53/23

F420-O:gamma-glutamyl ligase (CofE)

Halxa_3409, 258 aa, 85%

Nmag_2083, 133 aa, 4.68, 29/16

Probable F420-dependent oxidoreductase

Hbor_19440, 133 aa, 79%

Nmag_2231, 321 aa, 4.34, 64/20

Probable F420-dependent oxidoreductase

Slin_5283, 326 aa, 55%

Nmag_2631, 248 aa, 4.56, 37/18

2-phospho-L-lactate guanylyltransferase (CofC)

Halxa_1898, 226 aa, 63%

Nmag_2633, 389 aa, 4.25, 75/30

FO synthase subunit 1 (CofG)

Halxa_1896, 391 aa, 80%

Nmag_2637, 459 aa, 4.61, 84/42

FO synthase subunit 2 (CofH)

Halxa_1693, 456 aa, 86%

Nmag_3301, 318 aa, 4.35, 57/13

Probable F420-dependent oxidoreductase

Halxa_2620, 320 aa, 83%

Folate

Nmag_0002, 427 aa, 4.17, 83/31

Dihydropteroate synthase (FolP)

Htur_1844, 397 aa, 68%

Nmag_2300, 297 aa, 4.27, 57/24

Methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase (FolD)

Htur_1699, 297 aa, 92%

Nmag_2554, 840 aa, 4.37, 157/ 68

Folylpolyglutamate synthase/7,8-dihydropteroate reductase/dihydropteroate synthase (FolCP)

Htur_3284, 847 aa, 71%

Nmag_2792, 593 aa, 4.49, 113/61

Aminodeoxychorismate synthase component II (PabB)

Htur_1366, 537 aa, 70%

Nmag_2793, 298 aa, 4.28, 58/21

Aminodeoxychorismate synthase component I (PabA)

Htur_1365, 232 aa, 62%

Nmag_2794, 310 aa, 4.42, 52/25

Aminodeoxychorismate lyase (PabC)

Halxa_3973, 295 aa, 75%

Nmag_2853, 310 aa, 4.44, 68/29

GTP cyclohydrolase I, archaeal-type (MptA)

Halxa_1887, 311 aa, 93%

Nmag_2988, 183 aa, 4.17, 41/11

Dihydrofolate reductase (FolA)

Htur_1681, 181 aa, 79%

Heme/Siroheme/Cobalamin (common early pathway genes)

Nmag_0445, 573 aa, 4.39, 131/57

Glutamyl-tRNA synthetase (GltS)

Htur_2537, 574 aa, 83%

Nmag_1219, 457 aa, 4.17, 89/34

Glutamyl-tRNA reductase (HemA)

Htur_3246, 444 aa, 71%

Nmag_1220, 238 aa, 4.49, 43/26

Precorrin-2 oxidase (SirC) [may also have ferrochelatase activity]

Htur_3247, 218 aa, 69%

Nmag_2012, 242 aa, 4.00, 50/15

Uroporphyrinogen-III synthase (HemD)

Htur_3677, 255 aa, 74%

Nmag_2013, 283 aa, 4.39, 50/22

Uroporphyrin-III C-methyltransferase (SirA)

Htur_3676, 272 aa, 87%

Nmag_2014, 378 aa, 4.54, 77/41

Porphobilinogen deaminase (HemC)

Htur_3675, 380 aa, 85%

Nmag_2017, 424 aa, 4.57, 61/29

Glutamate-1-semialdehyde 2,1-aminomutase (HemL)

Halxa_1518, 424 aa, 88%

Nmag_2019, 333 aa, 4.69, 60/34

Porphobilinogen synthase (HemB)

Htur_0188, 341 aa, 81%

Cobalamin

Nmag_0392, 177 aa, 4.34, 39/16

ATP:cob(I)alamin adenosyltransferase (PudO)

Halxa_0779, 177 aa, 88%

Nmag_0846, 449 aa, 4.33, 90/34

CobW domain protein

Htur_2995, 410 aa, 61%

Nmag_0987, 340 aa, 5.33, 31/26

Adenosylcobinamide-phosphate synthase (CbiB)

Htur_2833, 378 aa, 66%

Nmag_0988, 253 aa, 7.90, 16/17

Cobalamin 5'-phosphate synthase (CobS)

Htur_2834, 253 aa, 71%

Nmag_0989, 243 aa, 4.50, 46/21

GTP:adenosylcobinamide-phosphate guanylyltransferase (CobY)

Htur_2835, 202 aa, 55%

Nmag_0990, 388 aa, 4.08, 67/22

Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (CobT)

Htur_2836, 349 aa, 72%

Nmag_0991, 383 aa, 4.46, 73/38

L-threonine-O-3-phosphate decarboxylase (CobD)

Htur_2837, 365 aa, 66%

Nmag_0992, 288 aa, 4.38, 39/ 16

Adenosylcobinamide amidohydrolase (CbiZ)

Htur_2838, 255 aa, 61%

Nmag_1837, 391 aa, 3.76,

ABC-type cobalamin transporter substrate-binding protein (BtuF)

Hmuk_2791, 377 aa, 42%

Nmag_2215, 400 aa, 4.40, 83/36

CobW domain protein

Htur_0421, 401 aa, 82%

Nmag_2216, 448 aa, 4.43, 98/37

CobW domain protein

Htur_0422, 442 aa, 71%

Nmag_3068, 563 aa, 4.59, 85/47

Adenosylcobyric acid synthase (CbiP)

Htur_5212, 538 aa, 71%

Nmag_3073, 239 aa, 4.56, 45/19

cob(I)alamin adenosyltransferase (CobA)

Htur_5207, 228 aa, 79%

Nmag_3175, 453 aa, 4.37, 79/31

Cobyrinic acid a,c-diamide synthase (CbiA)

Htur_0999, 437 aa, 76%

Nmag_3212, 301 aa, 4.27, 66/22

sirohydrochlorin cobaltochelatase (CbiX) [may instead be a ferrochelatase]

Htur_1053, 299 aa, 88%

Nmag_3605, 400 aa, 3.57, 92/13

ABC-type cobalamin transporter substrate-binding protein (BtuF)

Halxa_3346, 406 aa, 50%

Nmag_3606, 367 aa, 6.11, 19/15

ABC-type cobalamin transporter permease protein (BtuC)

Htur_1831, 376 aa, 78%

Nmag_3607, 536 aa, 4.17, 95/34

ABC-type cobalamin transporter ATPase protein (BtuD)

Halxa_3348, 440 aa, 63%

Nmag_4133, 424 aa, 4.01, 108/25

CobW domain protein

NP2376A, 428 aa, 81%

Heme/Siroheme

Nmag_0636, 283 aa, 9.00, 14/17

Heme A synthase (CtaA)

Halxa_2735, 289 aa, 70%

Nmag_1221, 363 aa, 4.47, 74/34

Siroheme decarboxylase (AhbB/NirGH)

Htur_3248, 360 aa, 83%

Nmag_2302, 495 aa, 5.92, 34/29

Protoheme IX geranylgeranyltransferase (CtaB)

Htur_1181, 482 aa, 79%

Nmag_2894, 349 aa, 4.33, 65/29

Siroheme decarboxylase (AhbA/NirDL)

Htur_0511, 346 aa, 77%