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Table 2 Top ten DEG after short waiting period comparing LPS-primed (P.) versus unstimulated control cells (C.)

From: Lipopolysaccharide priming enhances expression of effectors of immune defence while decreasing expression of pro-inflammatory cytokines in mammary epithelia cells from cows

Symbol

Entrez Gene Name

Mean ratio

Expression regulated by*

  

P./C.

IL1

TNF

IL6

IRF7

Priming enhances expression of:

    

   CCL5

chemokine (C-C motif) ligand 5

466

x

x

x

x

   SAA3

serum amyloid A3

146

x

   

   FAM14A

family with sequence similarity 14, member A

21

    

   HP

haptoglobin

14

x

x

x

 

   RTP4

receptor (chemosensory) transporter protein 4

13

    

   PARM1

prostate androgen-regulated mucin-like protein 1

8

    

   CFB

complement factor B

7

 

x

  

   PLAC8

placenta-specific 8

7

    

   HLA-DRA

major histocompatibility complex, class II, DR alpha

6

x

   

   MUC1

mucin 1, cell surface associated

5

x

x

  

Priming decreases expression of:

     

   ELTD1

EGF, latrophilin and seven transmembrane domain containing 1

-3.5

    

   TRIB3

tribbles homolog 3

-2.1

    

   TBXAS1

thromboxane A synthase 1

-2.0

    

   RASSF4

Ras association domain family 4

-2.0

    

   PYCR1

pyrroline-5-carboxylate reductase 1

-1.9

    

   G0S2

putative lymphocyte G0/G1 switch gene

-1.9

x

x

  

   FUT1

fucosyltransferase 1

-1.8

    

   C1orf24

chromosome 1 open reading frame 24

-1.8

    

   PCTP

phosphatidylcholine transfer protein

-1.6

    

   PSAT1

phosphoserine aminotransferase 1

-1.6

    
  1. * Expression of the respective gene is known to be regulated by IL1, TNF, IL6, and/or IRF7 (based on Ingenuity Knowledge Database).