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Table 2 Top ten DEG after short waiting period comparing LPS-primed (P.) versus unstimulated control cells (C.)

From: Lipopolysaccharide priming enhances expression of effectors of immune defence while decreasing expression of pro-inflammatory cytokines in mammary epithelia cells from cows

Symbol Entrez Gene Name Mean ratio Expression regulated by*
   P./C. IL1 TNF IL6 IRF7
Priming enhances expression of:     
   CCL5 chemokine (C-C motif) ligand 5 466 x x x x
   SAA3 serum amyloid A3 146 x    
   FAM14A family with sequence similarity 14, member A 21     
   HP haptoglobin 14 x x x  
   RTP4 receptor (chemosensory) transporter protein 4 13     
   PARM1 prostate androgen-regulated mucin-like protein 1 8     
   CFB complement factor B 7   x   
   PLAC8 placenta-specific 8 7     
   HLA-DRA major histocompatibility complex, class II, DR alpha 6 x    
   MUC1 mucin 1, cell surface associated 5 x x   
Priming decreases expression of:      
   ELTD1 EGF, latrophilin and seven transmembrane domain containing 1 -3.5     
   TRIB3 tribbles homolog 3 -2.1     
   TBXAS1 thromboxane A synthase 1 -2.0     
   RASSF4 Ras association domain family 4 -2.0     
   PYCR1 pyrroline-5-carboxylate reductase 1 -1.9     
   G0S2 putative lymphocyte G0/G1 switch gene -1.9 x x   
   FUT1 fucosyltransferase 1 -1.8     
   C1orf24 chromosome 1 open reading frame 24 -1.8     
   PCTP phosphatidylcholine transfer protein -1.6     
   PSAT1 phosphoserine aminotransferase 1 -1.6     
  1. * Expression of the respective gene is known to be regulated by IL1, TNF, IL6, and/or IRF7 (based on Ingenuity Knowledge Database).
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BMC Genomics

ISSN: 1471-2164

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