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Table 3 Priming-related modulation of gene expression subsequent to an E. coli challenge after a short waiting period

From: Lipopolysaccharide priming enhances expression of effectors of immune defence while decreasing expression of pro-inflammatory cytokines in mammary epithelia cells from cows

Symbol Entrez Gene Name Mean ratio Mean ratio compared to
un-stimulated control (C.)
Expression regulated by****
   I.p.P/I. I.p.P./C. I./C. P./C. IL1 TNF IL6 IRF7
Priming provokes a higher the expression level after an E. coli challenge of:
   CORO1A* coronin, actin binding protein, 1A 2.8** 2*** -2 2     
   CD55 CD55 molecule, decay accelerating factor for complement 2.6 2 -2 2 x x   
   HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1 2.3 4 2 4    x  
   TGM3 transglutaminase 3 2.3 4 2 2     
   SLPI secretory leukocyte peptidase inhibitor 2.2 5 2 4   x   
   LY6G6E lymphocyte antigen 6 complex, locus G6E 2.2 2 NC 2     
   CYP26A1 cytochrome P450, family 26, subfamily A, polypeptide 1 2.1 NC -2 2     
   DEFB4A defensin, beta 4A 2.1 47 22 24 x x   
   HLA-DRA major histocompatibility complex, class II, DR alpha 2.1 6 3 6 x    
   ATP6V0A4 ATPase, H+ transporting, lysosomal V0 subunit a4 2.0 NC -2 NC     
Priming provokes a lower expression level after an E. coli challenge of:
   NOS2 nitric oxide synthase 2, inducible -10.7 14 154 NC x x x  
   GBP2 guanylate binding protein 2, interferon-inducible -8.1 36 287 10 x x x  
   APOL3 apolipoprotein L, 3 -7.9 4 30 NC     
   IL1B interleukin 1, beta -6.4 5 32 NC x x   
   TIFA TRAF-interacting protein with forkhead-associated domain -6.0 6 36 NC     
   TNFSF13B tumor necrosis factor (ligand) superfamily, member 13b -5.8 15 89 NC   x   x
   TMEM140 transmembrane protein 140 -5.8 2 11 NC     
   GBP4 guanylate binding protein 4 -5.8 NC 6 NC   x   x
   LMO2 LIM domain only 2 (rhombotin-like 1) -5.3 NC 5 NC     
   RTP4 receptor (chemosensory) transporter protein 4 -4.7 15 72 4     x
  1. * bold letters, part of a network connected by the IPA relationship "Expression" (Fig 3B)
  2. ** bold numbers, fc > 1.5, p < 0.005
  3. *** italic number, fc > 1.5, p > 0.005
  4. NC, No change fc < 1.5
  5. **** Expression of the respective gene is known to be regulated by IL1, TNF, IL6, and/or IRF7 (based on Ingenuity Knowledge Database).