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Table 3 Priming-related modulation of gene expression subsequent to an E. coli challenge after a short waiting period

From: Lipopolysaccharide priming enhances expression of effectors of immune defence while decreasing expression of pro-inflammatory cytokines in mammary epithelia cells from cows

Symbol

Entrez Gene Name

Mean ratio

Mean ratio compared to

un-stimulated control (C.)

Expression regulated by****

  

I.p.P/I.

I.p.P./C.

I./C.

P./C.

IL1

TNF

IL6

IRF7

Priming provokes a higher the expression level after an E. coli challenge of:

   CORO1A*

coronin, actin binding protein, 1A

2.8**

2***

-2

2

    

   CD55

CD55 molecule, decay accelerating factor for complement

2.6

2

-2

2

x

x

  

   HLA-DQA1

major histocompatibility complex, class II, DQ alpha 1

2.3

4

2

4

  

x

 

   TGM3

transglutaminase 3

2.3

4

2

2

    

   SLPI

secretory leukocyte peptidase inhibitor

2.2

5

2

4

 

x

  

   LY6G6E

lymphocyte antigen 6 complex, locus G6E

2.2

2

NC

2

    

   CYP26A1

cytochrome P450, family 26, subfamily A, polypeptide 1

2.1

NC

-2

2

    

   DEFB4A

defensin, beta 4A

2.1

47

22

24

x

x

  

   HLA-DRA

major histocompatibility complex, class II, DR alpha

2.1

6

3

6

x

   

   ATP6V0A4

ATPase, H+ transporting, lysosomal V0 subunit a4

2.0

NC

-2

NC

    

Priming provokes a lower expression level after an E. coli challenge of:

   NOS2

nitric oxide synthase 2, inducible

-10.7

14

154

NC

x

x

x

 

   GBP2

guanylate binding protein 2, interferon-inducible

-8.1

36

287

10

x

x

x

 

   APOL3

apolipoprotein L, 3

-7.9

4

30

NC

    

   IL1B

interleukin 1, beta

-6.4

5

32

NC

x

x

  

   TIFA

TRAF-interacting protein with forkhead-associated domain

-6.0

6

36

NC

    

   TNFSF13B

tumor necrosis factor (ligand) superfamily, member 13b

-5.8

15

89

NC

 

x

 

x

   TMEM140

transmembrane protein 140

-5.8

2

11

NC

    

   GBP4

guanylate binding protein 4

-5.8

NC

6

NC

 

x

 

x

   LMO2

LIM domain only 2 (rhombotin-like 1)

-5.3

NC

5

NC

    

   RTP4

receptor (chemosensory) transporter protein 4

-4.7

15

72

4

   

x

  1. * bold letters, part of a network connected by the IPA relationship "Expression" (Fig 3B)
  2. ** bold numbers, fc > 1.5, p < 0.005
  3. *** italic number, fc > 1.5, p > 0.005
  4. NC, No change fc < 1.5
  5. **** Expression of the respective gene is known to be regulated by IL1, TNF, IL6, and/or IRF7 (based on Ingenuity Knowledge Database).
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BMC Genomics

ISSN: 1471-2164

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