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Table 2 Top 20 amino acid pairs displaying highest bias in terms of differences and ratios in number of forward (methanogens → sulphur metaboliser) and reverse (sulphur metaboliser → methanogen) replacements in 213 orthologous proteins from M.del to T. onn

From: A pursuit of lineage-specific and niche-specific proteome features in the world of archaea

Amino acid replacements between 213 orthologous proteins of M.del & T. onn
Most biased in gain Most biased in ratio
Pair Ratio Fwd. No Rev. No. Gain Pair Ratio Fwd. No. Rev. No. Gain
R → K 1.97## 871 443 428 Q → W 8.00* 8 1 7
E → K 2.03## 615 303 312 C → M 7.50** 15 2 13
D → E 1.58## 723 458 265 H → W 6.00** 18 3 15
S → K 3.91## 274 70 204 C → I 6.00## 30 5 25
D → K 2.84## 281 99 182 C → S 4.75## 38 8 30
S → A 1.65## 442 268 174 C → N 4.67** 14 3 11
S → E 2.41## 296 123 173 D → W 4.33* 13 3 10
I → L 1.20# 838 701 137 R → W 4.25## 34 8 26
R → E 1.40## 436 312 124 S → K 3.91## 274 70 204
M → L 1.45## 379 262 117 C → A 3.83## 92 24 68
G → K 2.22## 182 82 100 M → W 3.60** 18 5 13
T → V 1.48## 275 186 89 C → V 3.55## 71 20 51
A → K 1.77## 188 106 82 C → G 3.50** 21 6 15
L → F 1.30** 328 252 76 S → W 3.50* 14 4 10
M → I 1.51## 204 135 69 D → Y 3.24## 55 17 38
C → A 3.83## 92 24 68 C → T 3.20# 32 10 22
S → T 1.33** 275 207 68 C → F 3.17** 19 6 13
D → N 1.43# 216 151 65 D → K 2.84## 281 99 182
T → L 1.62## 165 102 63 V → W 2.70** 27 10 17
H → Y 2.21## 106 48 58 I → W 2.44* 22 9 13
  1. * significant at p < 0.05, ** significant at p < 0.01, # significant at p <0.001, ## significant at p < 0.0001.