Tps2 is epistatic to both Gpr1 and Ram1. Transcriptional changes upon the single deletion of either TPS2 or GPR1, as well as TPS2 or RAM1 are compared to the effect of their combined deletion. Shown are all transcripts (horizontal) changing significantly (p < 0.01, FC > 1.7) in any of the three deletion mutants (vertical). In both tps2Δ gpr1Δ and tps2Δ ram1Δ double deletions, transcriptional changes of tps2Δ dominate the double mutant gene expression profile. Colour scale as in Figure 2.