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Table 2 Core sporulation genes identified in the B. subtilis 168 genome

From: The genomic basis for the evolution of a novel form of cellular reproduction in the bacterium Epulopiscium

GENE REG FUNCTION
aprX K alkaline serine protease
bofA E inhibitor of the pro-σK processing machinery
cotI K spore coat protein
cotJB E component of the inner spore coat
cotJC E component of the inner spore coat
cotS K spore coat protein
csfB F anti-σG factor
cwlD E, G N-acetylmuramoyl-L-alanine amidase/germination
cwlJ E cell wall hydrolase/germination, cortex lytic
dacB E D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 5)
dacF F, G D-alanyl-D-alanine carboxypeptidase (penicilin-binding protein)
gerAA F, G component of the germination receptor GerA
gerAB F, G component of the germination receptor GerA
gerAC F, G component of the germination receptor GerA
gerBA G component of germinant receptor B
gerBB G component of germinant receptor B
gerBC G lipoprotein component of the germination receptor B
gerKA G spore germination receptor subunit
gerKB G spore germination receptor subunit
gerKC G spore germination receptor subunit
gpr F, G germination protease
jag A SpoIIIJ-associated RNA/ssDNA-binding protein
kamA E lysine 2,3-aminomutase
kapD E,K inhibitor of the KinA pathway to sporulation
lonB F ATP-dependent protease/forespore-specific
mmgC E short chain acyl-CoA dehydrogenase
ntdA E biosynthesis of neotrehalosadiamine (amino-sugar antibiotic)/aminotransferase
pbpG F, G penicillin-binding protein (also known as ywhE)
pbpI E, F penicillin-binding protein PBP4B/mother cell specific
pdaA G exported N-acetylmuramic acid deacetylase/cortex lysis
prkA E serine protein kinase/not well characterized
sigE A, 0A sporulation sigma factor/mother cell only
sigF H, 0A sporulation sigma factor/forespore only
sigG F, G sporulation sigma factor/forespore only
sigK E, K sporulation sigma factor/mother cell only
sleB G spore cortex-lytic enzyme
soj A, 0A chromosome partitioning protein/transcriptional regulator/negative regulation of sporulation initiation
splB G spore photoproduct (thymine dimer) lyase
spmA E spore maturation protein/spore dehydration
spmB E spore maturation protein/spore dehydration
spo0A A, H, 0A two-component response regulator central for the initiation of sporulation/"master regulator"
spo0F H, 0A two-component response regulator involved pathway leading to phosphorylation of Spo0A
spo0J A site-specific DNA-binding protein/chromosome positioning near the pole and transport through the polar septum/antagonist of Soj-dependent inhibition of sporulation initiation
spoIIAA H, 0A anti-anti-sigma factor (antagonist of SpoIIAB)
spoIIAB H, 0A anti-σF factor
spoIID E autolysin required for complete dissolution of the sporulation septum
spoIIE A, 0A serine phosphatase (σF activation)/polar septum formation
spoIIGA A, 0A protease processing pro-σE
spoIIIAA E ATP-binding stage III sporulation protein/mother cell signalling for σG activation
spoIIIAB E stage III sporulation protein/mother cell signalling for σG activation
spoIIIAC E stage III sporulation protein/mother cell signalling for σG activation
spoIIIAD E stage III sporulation protein/mother cell signalling for σG activation
spoIIIAE E stage III sporulation protein/mother cell signalling for σG activation
spoIIIAF E stage III sporulation protein/mother cell signalling for σG activation
spoIIIAG E stage III sporulation engulfment assembly protein/mother cell signalling for σG activation
spoIIIAH E stage III sporulation ratchet engulfment protein/mother cell signalling for σG activation
spoIIID E transcriptional regulator of σE and σK-dependent genes
spoIIIE A spore DNA translocase
spoIIIJ A protein translocase/essential for activation of σG
spoIIM E autolysin for dissolution of the septal cell wall
spoIIP E, F, G spore autolysin
spoIIR F endopeptidase/activation of σE
spoIVA E morphogenetic protein required for proper spore cortex formation and coat assembly
spoIVB F, G, 0A regulatory membrane-associated serine protease/intercompartmental signalling of pro-σK processing and activation in the mother-cell
spoIVFB E membrane metalloprotease required for the processing of pro-σK
spoVAA G dipicolinic acid uptake by the developing spore
spoVAB G dipicolinic acid uptake by the developing spore
spoVAC G dipicolinic acid uptake by the developing spore
spoVAD G dipicolinic acid uptake by the developing spore
spoVAEB G dipicolinic acid uptake by the developing spore
spoVAF G dipicolinic acid uptake by the developing spore
spoVB E spore cortex synthesis
spoVD E penicillin-binding protein
spoVE E spore cortex peptidoglycan synthesis
spoVFA K spore dipicolinate synthase subunit A
spoVFB K spore dipicolinate synthase subunit B
spoVR E spore cortex synthesis
spoVS H regulator required for dehydration of the spore core and assembly of the coat
spoVT F, G transcriptional regulator of σG-dependent genes
spsF K putative glycosyltransferase/spore coat polysaccharide synthesis
spsG E, K putative glycosyltransferase/spore coat polysaccharide synthesis
spsJ E, K putative dTDP-glucose 4,6-dehydratase/spore coat polysaccharide synthesis
sspA G small acid-soluble spore protein (alpha-type SASP)
sspB G small acid-soluble spore protein (beta-type SASP)
sspC G small acid-soluble spore protein (alpha/beta-type SASP)/SPβ phage protein
sspD G small acid-soluble spore protein (alpha/beta-type SASP)
sspF G small acid-soluble spore protein (alpha/beta-type SASP)
tlp F, G small acid-soluble spore protein
yaaH E spore peptidoglycan hydrolase
yabG K sporulation-specific protease
yabP E spore protein involved in the shaping of the spore coat
yabQ E membrane protein of the forespore/essential for spore cortex
ybaN E polysaccharide deacetylase involved in sporulation
ybdM G putative protein kinase
ycgF E putative amino acid export permease
ydfS K, G hypothetical protein
ydhD E spore cortex lytic enzyme
yerB 0A putative lipoprotein
yfkQ G putative spore germination protein
yfkR G putative spore germination protein
yfkT G putative spore germination integral inner membrane protein
yfnG K putative sugar-phosphate cytidylyltransferase
yfnH K putative FAD-dependent oxido-reductase
ygaK K putative FAD-dependent oxido-reductase
yhbH E hypothetical protein
yhcB G putative oxidoreductase associated
yhcV G putative oxidoreductase
yhfW F putative Rieske [2Fe-2S] oxygenase
yisY E putative hydrolase
ykuD K murein transglycosylase
ykuS F hypothetical protein
ykvU E spore membrane protein involved in germination
ylaK E putative phosphate starvation inducible protein
ylbB F putative oxidoreductase
ylbJ E putative factor required for spore cortex formation
ymxH E hypothetical protein
yndD G putative spore germination protein
yndE G putative spore germination integral inner membrane protein
yndF G putative spore germination lipoprotein
yngE E putative propionyl-CoA carboxylase
yngI E AMP-binding domain protein
yngJ E acyl-CoA dehydrogenase, short-chain specific
yoaR G putative factor for cell wall maintenance or synthesis
yobN E putative amine oxidase
ypeB G spore membrane component
yqfC E hypothetical protein
yqfD E stage IV sporulation protein
yqgT E putative gamma-D-glutamyl-L-diamino acid endopeptidase
yqhO E hypothetical protein
yraD G putative spore coat protein
yrbG E, G hypothetical protein
yrkC K putative dioxygenase; cupin family
ytcA K putative UDP-glucose dehydrogenase
ytcC K putative glucosyltransferase
ytfJ F hypothetical protein
ytlA K putative ABC transporter component
ytlC K putative ABC transporter component, ATP-binding
ytlD K putative permease of ABC transporter
ytvI E putative permease
ytxC E hypothetical protein
yunB E, K putative protein involved in spore formation
yutH F spore coat-associated protein
ywjD G putative UV damage endonuclease
yyaC F hypothetical protein
yyaE E putative oxidoreductase
yyaO K hypothetical protein
yyBI E inner spore coat protein