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Table 1 Genes upregulated by Tax (fold change ≥ 2.0, p < 0.05)

From: Visualizing spatiotemporal dynamics of apoptosis after G1 arrest by human T cell leukemia virus type 1 Tax and insights into gene expression changes using microarray-based gene expression analysis

Gene symbol

Gene description

Gene ID

Fold change

 

Transcription/Translation/RNA processing

  

FOXF1

forkhead box F1

2294

2.0

NFKB2

nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)

4791

2.0

NR6A1

nuclear receptor subfamily 6, group A, member 1

2649

2.0

CEBPD

CCAAT/enhancer binding protein (C/EBP), delta

1052

2.1

ETV5

ets variant 5

2119

2.1

FST

follistatin

10468

2.2

KLF6

Kruppel-like factor 6

1316

2.2

CEBPD

CCAAT/enhancer binding protein (C/EBP), delta

1052

2.3

EGR3

early growth response 3

1960

2.3

SAMD4A

sterile alpha motif domain containing 4A

23034

2.3

ELL2

elongation factor, RNA polymerase II, 2

22936

2.4

HIVEP2

human immunodeficiency virus type I enhancer binding protein 2

3097

2.4

MAFB

v-maf musculoaponeurotic fibrosarcoma oncogene homolog B (avian)

9935

2.4

FOSL2

FOS-like antigen 2

2355

2.5

ID2

inhibitor of DNA binding 2, dominant negative helix-loop-helix protein

3398

2.5

KLF2

Kruppel-like factor 2 (lung)

10365

2.5

RELB

v-rel reticuloendotheliosis viral oncogene homolog B

5971

2.5

MAFF

v-maf musculoaponeurotic fibrosarcoma oncogene homolog F (avian)

23764

2.8

LARP6

La ribonucleoprotein domain family, member 6

55323

3.1

REL

v-rel reticuloendotheliosis viral oncogene homolog (avian)

5966

3.1

FOSB

FBJ murine osteosarcoma viral oncogene homolog B

2354

3.2

HES1

hairy and enhancer of split 1 (Drosophila)

3280

3.2

SOD2

superoxide dismutase 2, mitochondrial

6648

3.4

ATF3

activating transcription factor 3

467

3.6

FOSL1

FOS-like antigen 1

8061

4.1

ZFP36

zinc finger protein 36, C3H type, homolog (mouse)

7538

4.2

ZNF331

zinc finger protein 331

55422

4.4

BACH2

BTB and CNC homology 1, basic leucine zipper transcription factor 2

60468

4.4

NFKBIE

nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon

4794

4.4

EGR1

early growth response 1

1958

6.2

FOS

FBJ murine osteosarcoma viral oncogene homolog

2353

8.4

NR4A2

nuclear receptor subfamily 4, group A, member 2

4929

10.9

 

Signal Transduction

  

EDN2

endothelin 2

1907

2.0

EPHA2

EPH receptor A2

1969

2.1

RIT1

Ras-like without CAAX 1

6016

2.1

SH2D3A

SH2 domain containing 3A

10045

2.1

KLRC1

killer cell lectin-like receptor subfamily C, member 1///killer cell lectin-like receptor subfamily C, member 2

3821

2.2

PSD4

pleckstrin and Sec7 domain containing 4

23550

2.5

ADM

adrenomedullin

133

2.7

GPRC5C

G-protein-coupled receptor, family C, group 5, member C

55890

2.7

BDKRB2

bradykinin receptor B2

624

2.8

GDF15

growth differentiation factor 15

9518

3.0

GPR87

G protein-coupled receptor 87

53836

3.4

RASA4

RAS p21 protein activator 4///RAS p21 protein activator 4 pseudogene

10156

8.8

GEM

GTP binding protein overexpressed in skeletal muscle

2669

14.1

GABBR1

gamma-aminobutyric acid (GABA) B receptor, 1///ubiquitin D

10537

24.5

RRAD

Ras-related associated with diabetes

6236

115.2

 

Inflammatory response/Immune response

  

KLRC1

killer cell lectin-like receptor subfamily C, member 1

3821

2.2

PTGS2

prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)

5743

2.3

CCL22

chemokine (C-C motif) ligand 22

6367

3.0

IL6R

interleukin 6 receptor

3570

3.0

TNIP1

TNFAIP3 interacting protein 1

10318

3.2

EBI3

Epstein-Barr virus induced 3

10148

3.2

IL27RA

interleukin 27 receptor, alpha

9466

3.5

TRIM22

tripartite motif-containing 22

10346

3.8

IL32

interleukin 32

9235

3.8

TNFAIP6

tumor necrosis factor, alpha-induced protein 6

7130

4.0

GBP2

guanylate binding protein 2, interferon-inducible

2634

5.2

GBP2

guanylate binding protein 2, interferon-inducible

2634

5.4

CCL19

chemokine (C-C motif) ligand 19

6363

6.2

CXCL1

chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)

2919

11.7

CXCL11

chemokine (C-X-C motif) ligand 11

6373

13.1

CXCL3

chemokine (C-X-C motif) ligand 3

2921

19.1

CCL20

chemokine (C-C motif) ligand 20

6364

20.1

PTX3

pentraxin-related gene, rapidly induced by IL-1 beta

5806

81.1

CXCL2

chemokine (C-X-C motif) ligand 2

2920

87.0

 

Apoptosis regulation

  

ZMAT3

zinc finger, matrin type 3

64393

2.0

JMJD6

jumonji domain containing 6

23210

2.0

AEN

apoptosis enhancing nuclease

64782

2.1

ADORA2A

adenosine A2a receptor

135

2.2

CD70

CD70 molecule

970

2.2

FAS

Fas (TNF receptor superfamily, member 6)

355

2.3

BAG3

BCL2-associated athanogene 3

9531

2.4

BIK

BCL2-interacting killer (apoptosis-inducing)

638

2.4

BCL6

B-cell CLL/lymphoma 6

604

2.7

TNFRSF1B

tumor necrosis factor receptor superfamily, member 1B

7133

3.3

ZC3H12A

zinc finger CCCH-type containing 12A

80149

4.1

NFKBIA

nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha

4792

5.2

NR4A1

nuclear receptor subfamily 4, group A, member 1

3164

5.4

IER3

immediate early response 3

8870

5.7

TNFAIP3

tumor necrosis factor, alpha-induced protein 3

7128

6.4

BTG2

BTG family, member 2

7832

7.0

TNFRSF9

tumor necrosis factor receptor superfamily, member 9

3604

8.2

BIRC3

baculoviral IAP repeat-containing 3

330

14.8

IL6

interleukin 6 (interferon, beta 2)

3569

18.0

 

Cell cycle regulation

  

GADD45A

growth arrest and DNA-damage-inducible, alpha

1647

2.2

RGS2

regulator of G-protein signaling 2, 24 kDa

5997

2.2

MAP3K8

mitogen-activated protein kinase kinase kinase 8

1326

2.3

SESN1

sestrin 1

27244

2.6

CDKN1A

cyclin-dependent kinase inhibitor 1A (p21, Cip1)

1026

2.8

CYLD

cylindromatosis (turban tumor syndrome)

1540

2.9

PLK2

polo-like kinase 2 (Drosophila)

10769

3.0

SMAD3

SMAD family member 3

4088

4.4

JUN

jun oncogene

3725

4.6

GADD45B

growth arrest and DNA-damage-inducible, beta

4616

4.8

DUSP1

dual specificity phosphatase 1

1843

8.5

IL8

interleukin 8

3576

41.7

 

Regulation of cell growth/Regulation of cell proliferation

  

ZMAT3

zinc finger, matrin type 3

64393

2.0

CSF1

colony stimulating factor 1 (macrophage)

1435

2.1

FGFR2

fibroblast growth factor receptor 2

2263

2.1

ABTB2

ankyrin repeat and BTB (POZ) domain containing 2

25841

2.4

SOCS2

suppressor of cytokine signaling 2

8835

2.4

PGF

placental growth factor

5228

2.6

HBEGF

heparin-binding EGF-like growth factor

1839

2.7

LIF

leukemia inhibitory factor (cholinergic differentiation factor)

3976

2.9

FGF18

fibroblast growth factor 18

8817

4.9

CCL2

chemokine (C-C motif) ligand 2

6347

6.7

IL11

interleukin 11

3589

7.4

RARRES1

retinoic acid receptor responder (tazarotene induced) 1

5918

7.5

IGFBP1

insulin-like growth factor binding protein 1

3484

32.2

DLGAP4

discs, large (Drosophila) homolog-associated protein 4

22839

2.5

EFNA1

ephrin-A1

1942

2.5

WNT4

wingless-type MMTV integration site family, member 4

54361

9.3

 

Cell adhesion

  

LYPD3

LY6/PLAUR domain containing 3

27076

2.0

PDZD2

PDZ domain containing 2

23037

2.1

FERMT2

fermitin family homolog 2 (Drosophila)

10979

2.2

NINJ1

ninjurin 1

4814

2.2

SIRPA

signal-regulatory protein alpha

140885

2.2

COL7A1

collagen, type VII, alpha 1

1294

2.3

LAMB3

laminin, beta 3

3914

2.6

CDH5

cadherin 5, type 2 (vascular endothelium)

1003

4.4

CTGF

connective tissue growth factor

1490

4.4

SAA1

serum amyloid A1///serum amyloid A2

6288

10.3

ICAM1

intercellular adhesion molecule 1

3383

10.8

 

Transport

  

SLC37A1

solute carrier family 37 (glycerol-3-phosphate transporter), member 1

54020

2.0

SLC1A3

solute carrier family 1 (glial high affinity glutamate transporter), member 3

6507

2.2

C19orf28

chromosome 19 open reading frame 28

126321

2.6

NPTX1

neuronal pentraxin I

4884

2.6

SLC2A6

solute carrier family 2 (facilitated glucose transporter), member 6

11182

3.5

HBA1

hemoglobin, alpha 1

3039

5.4

 

Metabolic process

  

HMGCS1

3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1 (soluble)

3157

2.0

PTGS1

prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)

5742

2.0

IDS

iduronate 2-sulfatase

3423

2.2

PI4K2A

phosphatidylinositol 4-kinase type 2 alpha

55361

2.2

PLA2G4C

phospholipase A2, group IVC (cytosolic, calcium-independent)

8605

2.2

C12orf5

chromosome 12 open reading frame 5

57103

2.3

PANX1

pannexin 1

24145

2.3

ABCA1

ATP-binding cassette, subfamily A (ABC1), member 1

19

2.4

AMPD3

adenosine monophosphate deaminase (isoform E)

272

2.4

SAT1

spermidine/spermine N1-acetyltransferase 1

6303

2.5

AKR1B1

aldo-keto reductase family 1, member B1 (aldose reductase)

231

2.6

GCNT3

glucosaminyl (N-acetyl) transferase 3, mucin type

9245

2.6

PITPNM1

phosphatidylinositol transfer protein, membrane-associated 1

9600

2.6

MICAL2

microtubule-associated monoxygenase, calponin and LIM domain containing 2

9645

3.2

PPAP2B

phosphatidic acid phosphatase type 2B

8613

3.2

ARG2

arginase, type II

384

4.1

PTGES

prostaglandin E synthase

9536

4.7

GFPT2

glutamine-fructose-6-phosphate transaminase 2

9945

5.0

 

Phosphorylation/Dephosphorylation

  

DUSP6

dual specificity phosphatase 6

1848

2.0

FAM129A

family with sequence similarity 129, member A

116496

2.3

DUSP13

dual specificity phosphatase 13

51207

2.6

DUSP5

dual specificity phosphatase 5

1847

4.1

PTPRE

protein tyrosine phosphatase, receptor type, E

5791

4.1

 

Response to stress

  

HSPA2

heat shock 70 kDa protein 2

3306

2.3

HSPA1A

heat shock 70 kDa protein 1A

3303

2.9

HSPB8

heat shock 22 kDa protein 8

26353

3.1

HSPB3

heat shock 27 kDa protein 3

8988

4.0

HSPB7

heat shock 27 kDa protein family, member 7 (cardiovascular)

27129

4.0

DNAJB1

DnaJ (Hsp40) homolog, subfamily B, member 1

3337

4.2

HSPA6

heat shock 70 kDa protein 6

3310

7.6

 

Ubiquitin

  

ENC1

ectodermal-neural cortex (with BTB-like domain)

8507

2.3

MAP1LC3C

microtubule-associated protein 1 light chain 3 gamma

440738

3.4

 

Others/Unknown

  

OLR1

oxidized low density lipoprotein (lectin-like) receptor 1

4973

2.0

TRIB1

tribbles homolog 1 (Drosophila)

10221

2.0

UNC13A

unc-13 homolog A (C. elegans)

23025

2.0

SNAI1

snail homolog 1 (Drosophila)

6615

2.1

FSTL3

follistatin-like 3 (secreted glycoprotein)

10272

2.2

GAB2

GRB2-associated binding protein 2

9846

2.2

PDLIM3

PDZ and LIM domain 3

27295

2.2

PMEPA1

prostate transmembrane protein, androgen induced 1

56937

2.2

SLC1A3

solute carrier family 1 (glial high affinity glutamate transporter), member 3

6507

2.2

FNDC3B

fibronectin type III domain containing 3B

64778

2.3

PHLDA3

pleckstrin homology-like domain, family A, member 3

23612

2.3

SLC25A4

solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4

291

2.3

TPM4

tropomyosin 4

7171

2.3

DSE

dermatan sulfate epimerase

29940

2.5

VEGFC

vascular endothelial growth factor C

7424

2.5

CSTA

cystatin A (stefin A)

1475

2.6

ZDHHC18

zinc finger, DHHC-type containing 18

84243

2.6

CDK2AP2

cyclin-dependent kinase 2 associated protein 2

10263

2.7

TIPARP

TCDD-inducible poly(ADP-ribose) polymerase

25976

2.7

CSTA

cystatin A (stefin A)

1475

2.8

TNFAIP2

tumor necrosis factor, alpha-induced protein 2

7127

2.8

PSD4

pleckstrin and Sec7 domain containing 4

23550

3.1

KRT17

keratin 17

3872

3.7

ARC

activity-regulated cytoskeleton-associated protein

23237

5.4

LXN

latexin

56925

5.5

TRIM31

tripartite motif-containing 31

11074

20.1

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BMC Genomics

ISSN: 1471-2164

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