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Table 1 Genes upregulated by Tax (fold change ≥ 2.0, p < 0.05)

From: Visualizing spatiotemporal dynamics of apoptosis after G1 arrest by human T cell leukemia virus type 1 Tax and insights into gene expression changes using microarray-based gene expression analysis

Gene symbol Gene description Gene ID Fold change
  Transcription/Translation/RNA processing   
FOXF1 forkhead box F1 2294 2.0
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100) 4791 2.0
NR6A1 nuclear receptor subfamily 6, group A, member 1 2649 2.0
CEBPD CCAAT/enhancer binding protein (C/EBP), delta 1052 2.1
ETV5 ets variant 5 2119 2.1
FST follistatin 10468 2.2
KLF6 Kruppel-like factor 6 1316 2.2
CEBPD CCAAT/enhancer binding protein (C/EBP), delta 1052 2.3
EGR3 early growth response 3 1960 2.3
SAMD4A sterile alpha motif domain containing 4A 23034 2.3
ELL2 elongation factor, RNA polymerase II, 2 22936 2.4
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 3097 2.4
MAFB v-maf musculoaponeurotic fibrosarcoma oncogene homolog B (avian) 9935 2.4
FOSL2 FOS-like antigen 2 2355 2.5
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein 3398 2.5
KLF2 Kruppel-like factor 2 (lung) 10365 2.5
RELB v-rel reticuloendotheliosis viral oncogene homolog B 5971 2.5
MAFF v-maf musculoaponeurotic fibrosarcoma oncogene homolog F (avian) 23764 2.8
LARP6 La ribonucleoprotein domain family, member 6 55323 3.1
REL v-rel reticuloendotheliosis viral oncogene homolog (avian) 5966 3.1
FOSB FBJ murine osteosarcoma viral oncogene homolog B 2354 3.2
HES1 hairy and enhancer of split 1 (Drosophila) 3280 3.2
SOD2 superoxide dismutase 2, mitochondrial 6648 3.4
ATF3 activating transcription factor 3 467 3.6
FOSL1 FOS-like antigen 1 8061 4.1
ZFP36 zinc finger protein 36, C3H type, homolog (mouse) 7538 4.2
ZNF331 zinc finger protein 331 55422 4.4
BACH2 BTB and CNC homology 1, basic leucine zipper transcription factor 2 60468 4.4
NFKBIE nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon 4794 4.4
EGR1 early growth response 1 1958 6.2
FOS FBJ murine osteosarcoma viral oncogene homolog 2353 8.4
NR4A2 nuclear receptor subfamily 4, group A, member 2 4929 10.9
  Signal Transduction   
EDN2 endothelin 2 1907 2.0
EPHA2 EPH receptor A2 1969 2.1
RIT1 Ras-like without CAAX 1 6016 2.1
SH2D3A SH2 domain containing 3A 10045 2.1
KLRC1 killer cell lectin-like receptor subfamily C, member 1///killer cell lectin-like receptor subfamily C, member 2 3821 2.2
PSD4 pleckstrin and Sec7 domain containing 4 23550 2.5
ADM adrenomedullin 133 2.7
GPRC5C G-protein-coupled receptor, family C, group 5, member C 55890 2.7
BDKRB2 bradykinin receptor B2 624 2.8
GDF15 growth differentiation factor 15 9518 3.0
GPR87 G protein-coupled receptor 87 53836 3.4
RASA4 RAS p21 protein activator 4///RAS p21 protein activator 4 pseudogene 10156 8.8
GEM GTP binding protein overexpressed in skeletal muscle 2669 14.1
GABBR1 gamma-aminobutyric acid (GABA) B receptor, 1///ubiquitin D 10537 24.5
RRAD Ras-related associated with diabetes 6236 115.2
  Inflammatory response/Immune response   
KLRC1 killer cell lectin-like receptor subfamily C, member 1 3821 2.2
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 5743 2.3
CCL22 chemokine (C-C motif) ligand 22 6367 3.0
IL6R interleukin 6 receptor 3570 3.0
TNIP1 TNFAIP3 interacting protein 1 10318 3.2
EBI3 Epstein-Barr virus induced 3 10148 3.2
IL27RA interleukin 27 receptor, alpha 9466 3.5
TRIM22 tripartite motif-containing 22 10346 3.8
IL32 interleukin 32 9235 3.8
TNFAIP6 tumor necrosis factor, alpha-induced protein 6 7130 4.0
GBP2 guanylate binding protein 2, interferon-inducible 2634 5.2
GBP2 guanylate binding protein 2, interferon-inducible 2634 5.4
CCL19 chemokine (C-C motif) ligand 19 6363 6.2
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) 2919 11.7
CXCL11 chemokine (C-X-C motif) ligand 11 6373 13.1
CXCL3 chemokine (C-X-C motif) ligand 3 2921 19.1
CCL20 chemokine (C-C motif) ligand 20 6364 20.1
PTX3 pentraxin-related gene, rapidly induced by IL-1 beta 5806 81.1
CXCL2 chemokine (C-X-C motif) ligand 2 2920 87.0
  Apoptosis regulation   
ZMAT3 zinc finger, matrin type 3 64393 2.0
JMJD6 jumonji domain containing 6 23210 2.0
AEN apoptosis enhancing nuclease 64782 2.1
ADORA2A adenosine A2a receptor 135 2.2
CD70 CD70 molecule 970 2.2
FAS Fas (TNF receptor superfamily, member 6) 355 2.3
BAG3 BCL2-associated athanogene 3 9531 2.4
BIK BCL2-interacting killer (apoptosis-inducing) 638 2.4
BCL6 B-cell CLL/lymphoma 6 604 2.7
TNFRSF1B tumor necrosis factor receptor superfamily, member 1B 7133 3.3
ZC3H12A zinc finger CCCH-type containing 12A 80149 4.1
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 4792 5.2
NR4A1 nuclear receptor subfamily 4, group A, member 1 3164 5.4
IER3 immediate early response 3 8870 5.7
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 7128 6.4
BTG2 BTG family, member 2 7832 7.0
TNFRSF9 tumor necrosis factor receptor superfamily, member 9 3604 8.2
BIRC3 baculoviral IAP repeat-containing 3 330 14.8
IL6 interleukin 6 (interferon, beta 2) 3569 18.0
  Cell cycle regulation   
GADD45A growth arrest and DNA-damage-inducible, alpha 1647 2.2
RGS2 regulator of G-protein signaling 2, 24 kDa 5997 2.2
MAP3K8 mitogen-activated protein kinase kinase kinase 8 1326 2.3
SESN1 sestrin 1 27244 2.6
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) 1026 2.8
CYLD cylindromatosis (turban tumor syndrome) 1540 2.9
PLK2 polo-like kinase 2 (Drosophila) 10769 3.0
SMAD3 SMAD family member 3 4088 4.4
JUN jun oncogene 3725 4.6
GADD45B growth arrest and DNA-damage-inducible, beta 4616 4.8
DUSP1 dual specificity phosphatase 1 1843 8.5
IL8 interleukin 8 3576 41.7
  Regulation of cell growth/Regulation of cell proliferation   
ZMAT3 zinc finger, matrin type 3 64393 2.0
CSF1 colony stimulating factor 1 (macrophage) 1435 2.1
FGFR2 fibroblast growth factor receptor 2 2263 2.1
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 25841 2.4
SOCS2 suppressor of cytokine signaling 2 8835 2.4
PGF placental growth factor 5228 2.6
HBEGF heparin-binding EGF-like growth factor 1839 2.7
LIF leukemia inhibitory factor (cholinergic differentiation factor) 3976 2.9
FGF18 fibroblast growth factor 18 8817 4.9
CCL2 chemokine (C-C motif) ligand 2 6347 6.7
IL11 interleukin 11 3589 7.4
RARRES1 retinoic acid receptor responder (tazarotene induced) 1 5918 7.5
IGFBP1 insulin-like growth factor binding protein 1 3484 32.2
DLGAP4 discs, large (Drosophila) homolog-associated protein 4 22839 2.5
EFNA1 ephrin-A1 1942 2.5
WNT4 wingless-type MMTV integration site family, member 4 54361 9.3
  Cell adhesion   
LYPD3 LY6/PLAUR domain containing 3 27076 2.0
PDZD2 PDZ domain containing 2 23037 2.1
FERMT2 fermitin family homolog 2 (Drosophila) 10979 2.2
NINJ1 ninjurin 1 4814 2.2
SIRPA signal-regulatory protein alpha 140885 2.2
COL7A1 collagen, type VII, alpha 1 1294 2.3
LAMB3 laminin, beta 3 3914 2.6
CDH5 cadherin 5, type 2 (vascular endothelium) 1003 4.4
CTGF connective tissue growth factor 1490 4.4
SAA1 serum amyloid A1///serum amyloid A2 6288 10.3
ICAM1 intercellular adhesion molecule 1 3383 10.8
  Transport   
SLC37A1 solute carrier family 37 (glycerol-3-phosphate transporter), member 1 54020 2.0
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3 6507 2.2
C19orf28 chromosome 19 open reading frame 28 126321 2.6
NPTX1 neuronal pentraxin I 4884 2.6
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6 11182 3.5
HBA1 hemoglobin, alpha 1 3039 5.4
  Metabolic process   
HMGCS1 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1 (soluble) 3157 2.0
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) 5742 2.0
IDS iduronate 2-sulfatase 3423 2.2
PI4K2A phosphatidylinositol 4-kinase type 2 alpha 55361 2.2
PLA2G4C phospholipase A2, group IVC (cytosolic, calcium-independent) 8605 2.2
C12orf5 chromosome 12 open reading frame 5 57103 2.3
PANX1 pannexin 1 24145 2.3
ABCA1 ATP-binding cassette, subfamily A (ABC1), member 1 19 2.4
AMPD3 adenosine monophosphate deaminase (isoform E) 272 2.4
SAT1 spermidine/spermine N1-acetyltransferase 1 6303 2.5
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase) 231 2.6
GCNT3 glucosaminyl (N-acetyl) transferase 3, mucin type 9245 2.6
PITPNM1 phosphatidylinositol transfer protein, membrane-associated 1 9600 2.6
MICAL2 microtubule-associated monoxygenase, calponin and LIM domain containing 2 9645 3.2
PPAP2B phosphatidic acid phosphatase type 2B 8613 3.2
ARG2 arginase, type II 384 4.1
PTGES prostaglandin E synthase 9536 4.7
GFPT2 glutamine-fructose-6-phosphate transaminase 2 9945 5.0
  Phosphorylation/Dephosphorylation   
DUSP6 dual specificity phosphatase 6 1848 2.0
FAM129A family with sequence similarity 129, member A 116496 2.3
DUSP13 dual specificity phosphatase 13 51207 2.6
DUSP5 dual specificity phosphatase 5 1847 4.1
PTPRE protein tyrosine phosphatase, receptor type, E 5791 4.1
  Response to stress   
HSPA2 heat shock 70 kDa protein 2 3306 2.3
HSPA1A heat shock 70 kDa protein 1A 3303 2.9
HSPB8 heat shock 22 kDa protein 8 26353 3.1
HSPB3 heat shock 27 kDa protein 3 8988 4.0
HSPB7 heat shock 27 kDa protein family, member 7 (cardiovascular) 27129 4.0
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1 3337 4.2
HSPA6 heat shock 70 kDa protein 6 3310 7.6
  Ubiquitin   
ENC1 ectodermal-neural cortex (with BTB-like domain) 8507 2.3
MAP1LC3C microtubule-associated protein 1 light chain 3 gamma 440738 3.4
  Others/Unknown   
OLR1 oxidized low density lipoprotein (lectin-like) receptor 1 4973 2.0
TRIB1 tribbles homolog 1 (Drosophila) 10221 2.0
UNC13A unc-13 homolog A (C. elegans) 23025 2.0
SNAI1 snail homolog 1 (Drosophila) 6615 2.1
FSTL3 follistatin-like 3 (secreted glycoprotein) 10272 2.2
GAB2 GRB2-associated binding protein 2 9846 2.2
PDLIM3 PDZ and LIM domain 3 27295 2.2
PMEPA1 prostate transmembrane protein, androgen induced 1 56937 2.2
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3 6507 2.2
FNDC3B fibronectin type III domain containing 3B 64778 2.3
PHLDA3 pleckstrin homology-like domain, family A, member 3 23612 2.3
SLC25A4 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4 291 2.3
TPM4 tropomyosin 4 7171 2.3
DSE dermatan sulfate epimerase 29940 2.5
VEGFC vascular endothelial growth factor C 7424 2.5
CSTA cystatin A (stefin A) 1475 2.6
ZDHHC18 zinc finger, DHHC-type containing 18 84243 2.6
CDK2AP2 cyclin-dependent kinase 2 associated protein 2 10263 2.7
TIPARP TCDD-inducible poly(ADP-ribose) polymerase 25976 2.7
CSTA cystatin A (stefin A) 1475 2.8
TNFAIP2 tumor necrosis factor, alpha-induced protein 2 7127 2.8
PSD4 pleckstrin and Sec7 domain containing 4 23550 3.1
KRT17 keratin 17 3872 3.7
ARC activity-regulated cytoskeleton-associated protein 23237 5.4
LXN latexin 56925 5.5
TRIM31 tripartite motif-containing 31 11074 20.1