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Figure 1 | BMC Genomics

Figure 1

From: Celiac disease T-cell epitopes from gamma-gliadins: immunoreactivity depends on the genome of origin, transcript frequency, and flanking protein variation

Figure 1

Schematic structure of a γ-gliadin protein. Structure of a γ-gliadin protein according to Anderson et al.[36] with the location of the CD epitopes. The protein consists of a short N-terminal signal peptide (S) followed by a unique N-terminal domain (I), two repetitive domains, R1 and R2 (II and IV) and two non-repetitive domains, NR1 and NR2 (III and V). In the first non-repetitive domain and in the second non-repetitive domain respectively six and two conserved cystein residues are present (indicated with vertical lines) that form four interchain disulfide bonds (indicated with arrows). The minimal T-cell epitopes are shown and their approximate position is indicated.

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