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Figure 3 | BMC Genomics

Figure 3

From: Celiac disease T-cell epitopes from gamma-gliadins: immunoreactivity depends on the genome of origin, transcript frequency, and flanking protein variation

Figure 3

CD-epitopes of γ-gliadin transcripts of T. aestivum in their natural context. The deduced aminoacid sequences of a T.aestivum γ-gliadin transcripts (N = 61) assigned to locus Gli-D, Neighbor Joining topology group 10, spanning a part of the first repetitive domain of the γ-gliadin sequence. CD T-cell epitopes are depicted: γ-I (PQQSFPQQQ), γ-III (QQPQQPYPQ), γ-IV (SQPQQQFPQ), γ-VI (QQPFPQQPQ), γ-VIIb (QQPQQPFPQ), 26-mer (FLQPQQPFPQQPQQPYPQQPQQPFPQ). Glutamine residues that are a primary targets for the enzyme tissue transglutaminase are underlined (Q) in QxP target sites whereas moderate target sites are depicted in italics (Q) [13, 14]. Cleavage sites: in grey with white letters, chymotrypsin-high specificity; in grey with black letters, chymotrypsin-low specificity; cleavage occurs at the right side (C-terminal direction) of the marked amino acid.

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