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Table 4 The DQ2- γ-II epitope in transcripts of T.aestivum

From: Celiac disease T-cell epitopes from gamma-gliadins: immunoreactivity depends on the genome of origin, transcript frequency, and flanking protein variation

 

1 2 3 4 5 6 7 8 9

 

locus

group

%

LVQGQ GI

IQPQ QPAQ L

EVIR SLVLGTLPTMCN

Gli-A1

6

19

LVQGQ GI

IQPQ QPAQ Y

EVIR SLVLR TLPNMCN

Gli-A1

7

5

LVQGQ GI

IQPQ QPAQ L

EVIR SLVLR TLPTMCN

Gli-B1

3

6

LVQGQ GI

IQPQ QLAQL

EAIR SLVLQTLPTMCN

Gli-B1

8

3

LAQGLGI

IQPQ QPAQL

EGIR SLVLK TLPTMCN

Gli-B1

5

17

LVQGQ GI

IQPQ QPAQL

EAIR SLVLQTLPSMCN

Gli-D1

9

41

LVQGQ GI

IQPQ QPAQL

EAIR SLVLQTLPTMCN

Gli-D1

10

9

  1. Natural variants of γ-II (glia-γ30; IQPQ QPAQ) epitope in expressed γ-gliadins of T.aestivum. This epitope is located in the C-terminal part of γ-gliadins (domain V). % = fraction of total number of γ-gliadins transcripts. Glutamine residues that are a primary targets for the enzyme tissue transglutaminase are to depicted in bold (Q) in QxP target sites whereas moderate target sites are depicted in italics, (Q) [13, 14]. Cleavage sites: R, K in bold, trypsin; cleavage occurs at the right side (C-terminal direction) of the marked amino acid.