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Table 4 The DQ2- γ-II epitope in transcripts of T.aestivum

From: Celiac disease T-cell epitopes from gamma-gliadins: immunoreactivity depends on the genome of origin, transcript frequency, and flanking protein variation

  1 2 3 4 5 6 7 8 9   locus group %
LVQGQ GI IQPQ QPAQ L EVIR SLVLGTLPTMCN Gli-A1 6 19
LVQGQ GI IQPQ QPAQ Y EVIR SLVLR TLPNMCN Gli-A1 7 5
LVQGQ GI IQPQ QPAQ L EVIR SLVLR TLPTMCN Gli-B1 3 6
LVQGQ GI IQPQ QLAQL EAIR SLVLQTLPTMCN Gli-B1 8 3
LAQGLGI IQPQ QPAQL EGIR SLVLK TLPTMCN Gli-B1 5 17
LVQGQ GI IQPQ QPAQL EAIR SLVLQTLPSMCN Gli-D1 9 41
LVQGQ GI IQPQ QPAQL EAIR SLVLQTLPTMCN Gli-D1 10 9
  1. Natural variants of γ-II (glia-γ30; IQPQ QPAQ) epitope in expressed γ-gliadins of T.aestivum. This epitope is located in the C-terminal part of γ-gliadins (domain V). % = fraction of total number of γ-gliadins transcripts. Glutamine residues that are a primary targets for the enzyme tissue transglutaminase are to depicted in bold (Q) in QxP target sites whereas moderate target sites are depicted in italics, (Q) [13, 14]. Cleavage sites: R, K in bold, trypsin; cleavage occurs at the right side (C-terminal direction) of the marked amino acid.