Skip to main content

Table 4 Top 50 canonical pathways found as significantly over-represented in present EST library

From: Expression sequence tag library derived from peripheral blood mononuclear cells of the chlorocebus sabaeus

Canonical pathway −log(q-value) gen a /gen b
Protein Ubiquitination Pathway 16.80 148/274 (54%)
Glucocorticoid Receptor Signaling 16.80 148/295 (50%)
Oxidative Phosphorylation 15.00 92/159 (58%)
Mitochondrial Dysfunction 14.00 86/175 (49%)
CD28 Signaling in T Helper Cells 13.70 77/132 (58%)
Regulation of eIF4 and p70S6K Signaling 11.90 69/132 (52%)
Role of NFAT in Regulation of the Immune Response 10.70 97/200 (49%)
EIF2 Signaling 10.60 57/101 (56%)
PI3K/AKT Signaling 10.50 73/140 (52%)
iCOS-iCOSL Signaling in T Helper Cells 10.50 67/122 (55%)
B Cell Receptor Signaling 10.10 83/156 (53%)
Regulation of IL-2 Expression in Lymphocytes 9.70 53/89 (60%)
Integrin Signaling 9.48 104/209 (50%)
PKCθ Signaling in T Lymphocytes 8.93 68/142 (48%)
Hypoxia Signaling in the Cardiovascular System 8.93 46/68 (68%)
CTLA4 Signaling in Cytotoxic T Lymphocytes 8.52 57/98 (58%)
mTOR Signaling 8.51 79/162 (49%)
T Cell Receptor Signaling 8.43 59/109 (54%)
Type I Diabetes Mellitus Signaling 8.32 64/121 (53%)
Production of Nitric Oxide and ROS in Macrophages 8.32 83/187 (44%)
Ubiquinone Biosynthesis 8.05 45/112 (40%)
Molecular Mechanisms of Cancer 7.64 152/377 (40%)
Estrogen Receptor Signaling 7.54 70/136 (51%)
Antigen Presentation Pathway 7.20 30/43 (70%)
Apoptosis Signaling 7.19 53/96 (55%)
G2/M DNA Damage Checkpoint Regulation 7.19 32/49 (65%)
Prostate Cancer Signaling 6.96 49/97 (51%)
Phospholipase C Signaling 6.79 109/260 (42%)
Huntington’s Disease Signaling 6.78 104/238 (44%)
Chronic Myeloid Leukemia Signaling 6.65 54/105 (51%)
Pancreatic Adenocarcinoma Signaling 6.61 59/119 (50%)
IL-8 Signaling 6.60 86/193 (45%)
PI3K Signaling in B Lymphocytes 6.50 69/143 (48%)
Breast Cancer Regulation by Stathmin1 6.49 93/208 (45%)
IL-2 Signaling 6.31 35/58 (60%)
NF-κ B Activation by Viruses 6.26 44/82 (54%)
IL-15 Signaling 6.23 39/68 (57%)
T Helper Cell Differentiation 6.15 42/72 (58%)
TREM1 Signaling 6.05 35/66 (53%)
Fcγ Receptor-mediated Phagocytosis in Macrophages 5.98 52/102 (51%)
Pyrimidine Metabolism 5.85 70/213 (33%)
GM-CSF Signaling 5.69 38/67 (57%)
Induction of Apoptosis by HIV1 5.64 37/66 (56%)
Dendritic Cell Maturation 5.64 78/188 (41%)
NRF2-mediated Oxidative Stress Response 5.63 86/193 (45%)
Purine Metabolism 5.56 117/391 (30%)
fMLP Signaling in Neutrophils 5.50 57/128 (45%)
JAK/Stat Signaling 5.42 37/64 (58%)
HMGB1 Signaling 5.40 51/100 (51%)
IL-4 Signaling 5.40 40/73 (55%)
  1. List of the top 50 canonical pathways found as statistically significantly over-represented in the functional pathway analysis of the EST library. For each canonical pathway, the associated multiple testing corrected p-value (shown as −log(q-value)) is indicated as well as the ratio between the number ge n a of genes of the pathway mapped by the EST library and the total number ge n b of genes defining the pathway.