Table 4 Top 50 canonical pathways found as significantly over-represented in present EST library
Canonical pathway | −log(q-value) | gen a /gen b |
|---|---|---|
Protein Ubiquitination Pathway | 16.80 | 148/274 (54%) |
Glucocorticoid Receptor Signaling | 16.80 | 148/295 (50%) |
Oxidative Phosphorylation | 15.00 | 92/159 (58%) |
Mitochondrial Dysfunction | 14.00 | 86/175 (49%) |
CD28 Signaling in T Helper Cells | 13.70 | 77/132 (58%) |
Regulation of eIF4 and p70S6K Signaling | 11.90 | 69/132 (52%) |
Role of NFAT in Regulation of the Immune Response | 10.70 | 97/200 (49%) |
EIF2 Signaling | 10.60 | 57/101 (56%) |
PI3K/AKT Signaling | 10.50 | 73/140 (52%) |
iCOS-iCOSL Signaling in T Helper Cells | 10.50 | 67/122 (55%) |
B Cell Receptor Signaling | 10.10 | 83/156 (53%) |
Regulation of IL-2 Expression in Lymphocytes | 9.70 | 53/89 (60%) |
Integrin Signaling | 9.48 | 104/209 (50%) |
PKCθ Signaling in T Lymphocytes | 8.93 | 68/142 (48%) |
Hypoxia Signaling in the Cardiovascular System | 8.93 | 46/68 (68%) |
CTLA4 Signaling in Cytotoxic T Lymphocytes | 8.52 | 57/98 (58%) |
mTOR Signaling | 8.51 | 79/162 (49%) |
T Cell Receptor Signaling | 8.43 | 59/109 (54%) |
Type I Diabetes Mellitus Signaling | 8.32 | 64/121 (53%) |
Production of Nitric Oxide and ROS in Macrophages | 8.32 | 83/187 (44%) |
Ubiquinone Biosynthesis | 8.05 | 45/112 (40%) |
Molecular Mechanisms of Cancer | 7.64 | 152/377 (40%) |
Estrogen Receptor Signaling | 7.54 | 70/136 (51%) |
Antigen Presentation Pathway | 7.20 | 30/43 (70%) |
Apoptosis Signaling | 7.19 | 53/96 (55%) |
G2/M DNA Damage Checkpoint Regulation | 7.19 | 32/49 (65%) |
Prostate Cancer Signaling | 6.96 | 49/97 (51%) |
Phospholipase C Signaling | 6.79 | 109/260 (42%) |
Huntington’s Disease Signaling | 6.78 | 104/238 (44%) |
Chronic Myeloid Leukemia Signaling | 6.65 | 54/105 (51%) |
Pancreatic Adenocarcinoma Signaling | 6.61 | 59/119 (50%) |
IL-8 Signaling | 6.60 | 86/193 (45%) |
PI3K Signaling in B Lymphocytes | 6.50 | 69/143 (48%) |
Breast Cancer Regulation by Stathmin1 | 6.49 | 93/208 (45%) |
IL-2 Signaling | 6.31 | 35/58 (60%) |
NF-κ B Activation by Viruses | 6.26 | 44/82 (54%) |
IL-15 Signaling | 6.23 | 39/68 (57%) |
T Helper Cell Differentiation | 6.15 | 42/72 (58%) |
TREM1 Signaling | 6.05 | 35/66 (53%) |
Fcγ Receptor-mediated Phagocytosis in Macrophages | 5.98 | 52/102 (51%) |
Pyrimidine Metabolism | 5.85 | 70/213 (33%) |
GM-CSF Signaling | 5.69 | 38/67 (57%) |
Induction of Apoptosis by HIV1 | 5.64 | 37/66 (56%) |
Dendritic Cell Maturation | 5.64 | 78/188 (41%) |
NRF2-mediated Oxidative Stress Response | 5.63 | 86/193 (45%) |
Purine Metabolism | 5.56 | 117/391 (30%) |
fMLP Signaling in Neutrophils | 5.50 | 57/128 (45%) |
JAK/Stat Signaling | 5.42 | 37/64 (58%) |
HMGB1 Signaling | 5.40 | 51/100 (51%) |
IL-4 Signaling | 5.40 | 40/73 (55%) |