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Figure 2 | BMC Genomics

Figure 2

From: Increased sensitivity of next generation sequencing-based expression profiling after globin reduction in human blood RNA

Figure 2

Differential expression of non-globin reduced versus globin reduced whole blood samples. A. MA-plot (log concentration on x-axis, log fold-change on y-axis) showing that the majority of differentially expressed genes (P value < 0.01, indicated in red) are up-regulated while the 4 globin genes showed the strongest reduction. Genes with zero expression in one of the groups are shown on the left end of the plot. HBD: hemoglobin delta, HBB: hemoglobin beta, HBA1: hemoglobin alpha 1, HBA1: hemoglobin alpha 2. CXorf25 has a logConc of -18.79 and a logFC of -14.3 and is not shown on this graph. B. Heatmap of normalised expression values of 21633 genes across the 6 non reduced and 6 reduced (R) samples where green depicts high expression and red low expression values.

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BMC Genomics

ISSN: 1471-2164

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