Comparison of A) list-based methods of network construction and B) NetWalk. In list-based network construction, interacting genes (open nodes) are added to the network of seed nodes (red) to connect them together. This will generate a single or a number of networks of interest. Distribution of data values of interactor nodes are random. In contrast, NetWalk transforms gene-centric data to interaction-centric data, which can be used for standard statistical analyses (e.g. heatmap analyses) or for dynamic network construction. Data values of nodes constructed through EF values are coherent with input values (see ref.7 for details).