Table 2 Summary of the most highly expressed transcripts of toxins expressed in the venom duct
Pharmacological Sites Most Frequently Targeted | Rank of Site | Peptides Targeting Site | Sequence of Predicted Mature Venom Peptide | Total Reads | Distribution (% in quadrant) | |||
|---|---|---|---|---|---|---|---|---|
| Â | Â | Â | Â | Â | P | PC | DC | D |
NMDA Receptor (NR2B Subunit) | 1 | ConG | GEγγVQγNQγLIRγASNGKR | 65,820 | 0.2 | 0.3 | 47.8 | 51.6 |
|  |  | ConG* | GEγγLQγNQγLIRγKSNGKR | 90,531 | 0.7 | 0.4 | 34.4 | 64.6 |
Nav 1.4 (outer pore vestibule) | 2 | μ-GIIIA | RDCCTPPKKCKDRQCKPQRCCAGR | 1,090 | 46.0 | 41.6 | 12.5 | 0.0 |
|  |  | μ-GIIIB | RDCCTPPRKCKDRRCKPMKCCAGR | 110,980 | 41.2 | 43.2 | 15.0 | 0.5 |
Nicotinic AChR (Adult Muscle, αδ interface) | 3 | α-GI | ECCNPACGRHYSCGR | 6, 431 | 50.7 | 40.4 | 8.6 | 0.4 |
|  |  | α-GIB | ECCNPACGRHYSCKGGR | 29,256 | 24.8 | 60.8 | 13.9 | 0.4 |
|  |  | α-GII | ECCHPACGKHFSCGR | 27,753 | 43.4 | 42.0 | 14.3 | 0.3 |
? Nicotinic AChR (Fetal Muscle, αγ interface) | 4 | αA(G4.1) | CCGKPNAACHPCVCNGSCSGRR | 36,087 | 8.8 | 72.9 | 17.5 | 0.8 |
|  |  | αA(G4.2) | CCGKPNAACHPCVCNGSCSGGR | 4,262 | 4.5 | 79.1 | 15.7 | 0.7 |
|  |  | αA(G4.3) | CCGKPTSACHPCVCNGSCSGGR | 461 | 20.0 | 62.7 | 16.5 | 0.9 |
Neuronal nAChR (Subtype uncertain) | 5 | α-GID | ECCSNPACRVNNPHVCRRR | 19,350 | 41.6 | 44.9 | 12.4 | 1.2 |
Calcium Channel (Subtype uncertain) | 6 | ωGVIIA ωGVIIB* | CKSPGTPCSRGMRDCCTSCLLYSNKCRRY | 5,992 | 43.9 | 44.6 | 10.1 | 1.3 |
| Â | Â | Â | CKSPGTPCSRTMRDCCTSCLSYSKKCRG | 3,859 | 24.0 | 48.9 | 16.9 | 10.2 |
? Ca Channel(Unknown) | 7 | (G20) | CVPSGGSCSRTAYSCCHGSCSGGRCG | 3,767 | 30.2 | 42.3 | 20.7 | 6.7 |
Calcium Channel (Cav2.2 subtype, outer vestibule) | 8 | ωGVIA | CKSPGSSCSPTSYNCCRSCNPYTKRCYG | 3,611 | 61.0 | 18.6 | 11.3 | 9.2 |