Figure 4

Functional annotation clustering of BMP2 and TSA treated neurosphere cultures at different time points. Differentially expressed genes (relative expression >2-fold and absolute difference >100. comparing treated and control sample, confidence >90%) are functionally clustered using DAVID Database. Functional groups with an enrichment score >1.5 are exhibited. The enrichment score is the geometric mean (in -log scale) of member's p-values in a corresponding annotation cluster. The number of genes in each cluster is represented as bars, the corresponding enrichment scores are illustrated as dots. Functional annotation of genes altered in individual treatments with TSA after 6 h (A) and 24 h (B), BMP2 after 6 h (C) and 24 h (D) as well as of intersectional genes regulated after treatment with BMP2 24 h and TSA 24 h (E) are displayed.