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Table 4 The downward effect of JTX on the gene expression in the small intestine in IQI GF mice

From: Microarray analysis on germfree mice elucidates the primary target of a traditional Japanese medicine juzentaihoto: acceleration of IFN-α response via affecting the ISGF3-IRF7 signaling cascade

GFSI-down     
Probe Set ID Gene Name Gene Symbol Entre ID Fold Change p-value
103842_at DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, Y-linked Ddx3y 26900 0.01 0.006
103674_f_at eukaryotic translation initiation factor 2, subunit 3, structural gene Y-linked Eif2s3y 26908 0.03 0.022
95024_at ubiquitin specific peptidase 18 Usp18 24110 0.11 0.003
100981_at interferon-induced protein with tetratricopeptide repeats 1 Ifit1 15957 0.15 0.010
93956_at interferon-induced protein with tetratricopeptide repeats 3 Ifit3 15959 0.17 0.009
160933_at interferon gamma induced GTPase Igtp 16145 0.19 0.000
98822_at ISG15 ubiquitin-like modifier G1p2 53606 0.20 0.035
92718_at interferon, alpha-inducible protein 27 Ifi27 76933 0.24 0.019
104750_at interferon gamma inducible protein 47 Ifi47 15953 0.25 0.009
98030_at tripartite motif protein 30 Trim30 20128 0.25 0.003
104177_at radical S-adenosyl methionine domain containing 2 Rsad2 58185 0.27 0.004
102906_at T-cell specific GTPase Tgtp 21822 0.29 0.000
92472_f_at schlafen 2 Slfn2 20556 0.31 0.004
98410_at interferon inducible GTPase 2 Iigp2 54396 0.32 0.007
103066_at thymidylate kinase family LPS-inducible member Tyki 22169 0.36 0.024
97409_at immunity-related GTPase family, M Irgm 15944 0.36 0.021
103446_at interferon induced with helicase C domain 1 Ifih1 71586 0.39 0.010
102699_at myxovirus (influenza virus) resistance 2 Mx2 17858 0.42 0.012
93078_at lymphocyte antigen 6 complex, locus A Ly6a 110454 0.43 0.030
160668_at opioid growth factor receptor Ogfr 72075 0.44 0.006
103254_at TRAF type zinc finger domain containing 1 Trafd1 231712 0.44 0.043
103202_at guanylate nucleotide binding protein 4 Gbp4 55932 0.44 0.013
101465_at signal transducer and activator of transcription 1 Stat1 20846 0.44 0.021
103634_at interferon dependent positive acting transcription factor 3 gamma Isgf3g 16391 0.47 0.006
103035_at transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) Tap1 21354 0.48 0.027
103080_at SAM domain and HD domain, 1 Samhd1 56045 0.50 0.016
103812_at chloride channel calcium activated 1 Clca1 12722 0.50 0.019
160847_at tRNA nucleotidyl transferase, CCA-adding, 1 Trnt1 70047 0.52 0.014
102873_at transporter 2, ATP-binding cassette, sub-family B (MDR/TAP) Tap2 21355 0.57 0.037
100475_at tripartite motif protein 25 Trim25 217069 0.58 0.025
98283_at 5'-3' exoribonuclease 1 Xrn1 24127 0.61 0.005
96151_at Molybdenum cofactor sulfurase Mocos 68591 0.61 0.010
102812_i_at ubiquitin-activating enzyme E1-domain containing 1 Ube1dc1 66663 0.62 0.003
94461_at pre-B-cell colony-enhancing factor 1 Pbef1 59027 0.62 0.030
95886_g_at CREB binding protein Crebbp 12914 0.63 0.012
103673_at complement component 2 (within H-2S) C2 12263 0.63 0.013
97921_at Agrin Agrn 11603 0.63 0.043
102279_at ubiquitin-activating enzyme E1-like Ube1l 74153 0.64 0.013
104070_at p300/CBP-associated factor Pcaf 18519 0.64 0.002
96157_at zinc finger protein 91 Zfp91 109910 0.65 0.009
94192_at ganglioside-induced differentiation-associated-protein 10 Gdap10 14546 0.66 0.049
103025_at Moloney leukemia virus 10 Mov10 17454 0.67 0.042
  1. The genes whose change was < 0.67 fold and with p < 0.1 (n = 3, Welch's t test) were the listed sorted by fold-change. Eight immunoglobulin genes and 14 unidentified probe sets were omitted from the lists. The genes appeared commonly in both Tables 3 and 4 were in bold letters. The genes appeared commonly in Tables 1 and 4 were underlined.