Statistics of enhancer biclusters. A) Enhancer coverage of all 26 possible histone states involving at least two histone modification marks. Y-axis, percentages of enhancers in biclusters that are associated with a given histone state. Histone marks of each state is indicated at the bottom of the histogram. Each column represents a histone state with the filled square indicating the presence of a histone mark in the state and empty square otherwise. Asterisk, histone states shared by all three cell types and cover at least 1% of the enhancers. B) Histone mark occurrence frequencies in the genome and in the 16 common biclusters shared among three cell types. Frequencies are indicated by the length of the bar for genomic and bicluster categories separately. C) Normalized co-occurrence frequencies of histone mark pairs in the 16 common biclusters shared by all three cell types. Shown are log ratios (base 10) of observed versus expected frequencies of histone mark pairs. Expected frequencies are calculated using genomic frequencies of individual histone marks.