Brain transcriptome variation among behaviorally distinct strains of zebrafish (Danio rerio)

BMC Genomics

Table 1 Related genes with brain expression patterns associated with domestication in multiple species

Genes	Zebrafish Strain	Zebrafish Domestication	Rainbow Trout Domestication[[37]]	Fox Tameness[[35]]	Dog-Wolf Comparison[[36]]	Mouse Behavior[[47]]
Caspase	casp2, casp3a, caspb	casp3a (+)	casp8 (+)
Coiled-coil domain containing	ccdc47, ccdc53, ccdc93, Dr.18793.1.A1_at	Dr.18793.1.A1_at (+)	BU965755 (+)
Collagens	col1a2, col2a1a, col5a2l, col9a2, wu:fa99c11, zgc:56518		col1a1 (+), col1a2 (+)			col1a1^a, col3a1^b
Cytochrome c oxidase			cox2 (–), cox3 (–)			cox5a^b
DNAj	dnajc12	dnajc3 (–)				dnajc6(AI840916)^c
Eukaryotic translation initiation factors	eif1ax, eif4enif1	eif1ax (+), eif4enif1 (–)	eif3s2 (+), eif3s7 (+)
Glutathione peroxidases	gpx1a, gpx4a		gpx3 (–)			gpx3^d
Hemoglobins	hbaa1, ba1		hba,hba1, hba4, hbb, hbb1, hbb2, hbb4 (all +)	hbe, hbg1, hbg2, hba, hbz (all –)		hbaa1^e
NADH dehydrogenase (ubiquinone)			ndf1a4 (+)	ndufb8 (–)
Neurofilament, light peptide			CB514125 (+)			nefl^e
Potassium channel proteins	Dr.16785.1.A1_at (kcnk1)				kcnj4 (–)	AI835316 (kcnc2)^a
Purkinje cell protein 4				pcp4 (*)	pcp4 (+)
Selenoprotein P	sepp1a	sepp1a (+)			sepp1 (+)
Syntaxins	stx3a, stx6, syntaxin1b			stx1b2 (+)
Syntaxin binding proteins			stxbp3 (+)			stxbp2^b, stxbp6^e
Transthyretin (prealbumin, amyloidosis type I)				ttr (*)	ttr (+)

Studies included the present study on zebrafish (Danio rerio), an analysis of domestication in rainbow trout (Oncorhynchus mykiss) [37], silver fox (Vulpes vulpes) selected for tameness [35], a comparison between dog (Canis familiaris) and wolf (Canius lupus) [36], and an analysis of strain variation in laboratory mice (Mus musculus) [47]. Positive signs (+) indicated up-regulation in domesticated populations relative to wild, while negative signs (–) indicate down-regulation. An asterisk (*) indicates that the direction of differential expression differed among brain regions.
^a Negative correlation with open field activity; ^b Positive correlation with distance traveled after ethanol administration; ^c Positive correlation with electroconvulsive threshold; ^d Negative correlation with electroconvulsive threshold; ^e Positive correlation with open field activity.

ISSN: 1471-2164