Figure 4

Transcriptional similarities between the fetal liver and pancreas in humans. A. Fetal liver exhibits greater similarity to pancreas than adult liver in humans. The biological replicates were clustered using hierarchical clustering. B. Overlap in the genes differentially expressed in the fetal liver or pancreas compared to the adult liver. C. Concordance in the direction and intensity of the fold-changes in the 1271 human overlapping genes from B. The intensity scale indicates fold-changes compared to the adult livers. Red, up-regulation; green, down-regulation. D. Common canonical pathways in mice and humans that are altered in fetal liver and pancreas compared to adult liver. Genes were divided into those depicted in the Venn diagrams in Figure 3C and Figure 4B as 1) expressed in fetal liver only, 2) common to pancreas and fetal liver and 3) in pancreas only. These 3 groups were analyzed using IPA before and after separation into up- and down-regulated genes. The same canonical pathways were compared between mice and humans. The scale is described in Figure 2 legend.