A microRNA activity map of human mesenchymal tumors: connections to oncogenic pathways; an integrative transcriptomic study

Table 5 Summary of predicted RAS-related miRNA targets

miRNA	RAS + Tumors	RAS- Tumors	Target Scan Predictions	miRanda Predictions
hsa-miR-200b	On	Off		DROSHA
hsa-miR-27b	On	Off	EIF2C2, DROSHA	EIF2C2, DROSHA
hsa-miR-424	On	Off	DICER1, TARBP2	EIF2C2, TARBP2
hsa-miR-99a	On	Off	EIF2C2	EIF2C2
hsa-miR-200c	On	Off		DROSHA
hsa-miR-31	On	Off	DICER1, DGCR8	DICER1, DGCR8
hsa-miR-15a	On	Off	DICER1, TARBP2	EIF2C2, DICER1, TARBP2
hsa-miR-16	On	Off	DICER1, TARBP2	EIF2C2, DICER1, TARBP2
hsa-miR-27a	On	Off	EIF2C2, DROSHA	EIF2C2, DROSHA

Predicted mRNA targets of "RAS-switching" miRNAs related to miRNA processing are summarized. The columns denoted "RAS + Tumors" and "RAS- Tumors" indicate whether RAS-switching miRNAs are activated (On) or inactivated (Off) relative to normal tissue for RAS-active and RAS-inactive tumors respectively.

ISSN: 1471-2164