Table 1 Large families of secreted proteins with known domains
From: A survey of putative secreted and transmembrane proteins encoded in the C. elegans genome
Group | Noa | Upregulated upon infection | Size range (aa) | Â | Typical domain organization | Comments |
|---|---|---|---|---|---|---|
small C-type lectins | 236 (184) | 83 | 120-650 | clec-1 |
| proteins with a C-type lectin domain |
clec-66 |
| Â | ||||
clec-254 |
| Â | ||||
clec-55 |
| Â | ||||
collagens | 168 (108) | 77 | 270-500 | dpy-5 |
| putative cuticular collagens |
ShK proteins | 66 (52) | 26 | 120-300 | phat-3 |
| proteins containing multiple copies of the ShK toxin domain |
Transthyretin-like | 56 (46) | 24 | 120-190 | ttr-1 |
| transthyretin-related proteins |
RcpL-genes | 51 (38) | 1 | 300-550 | F58E1.4 |
| RcpL is the ligand binding domain in the EGF-receptor (let- 23) and the insulin-receptor (daf- 2) |
small CUBproteins | 43 (38) | 30 | 300-600 | dct-17 |
| many members have no predicted signal peptide |
insulins | 39 (37) | 19 | 70-130 | ins-1 |
| insulin-like peptides |
grd- and grl-genes | 46 (44) | 23 | 140-450 | grl-1 |
| groundhog proteins (hedgehog related proteins) |
scl-genes | 28 (27) | 5 | 200-250 | scl-2 |
| contains lon-1 |
Ctx-genes | 29 (24) | 9 | 300-570 | Â |
| proteins containing multiple copies of a cysteine-rich repeat (Ctx) |
abu-9 |
| |||||
VOMI proteins | 19 (13) | 5 | 100-360 | C18D4.4 |
| Vitelline membrane outer layer protein I |
large KU/DC proteins | 12 (12) | 3 | 920-1800 | ZC84.1 | (see Figure3 complex proteins) | proteins containing tandem copies of Kunitz and DC domains |
spp-genes (SapB) | 23 (21) | 12 | 100-400 | spp-1 |
| saposin-like protein family |
wrt-genes | 10 (10) | 6 | 180-550 | wrt-1 |
| warthog proteins (hedgehogrelated proteins) |
