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Table 1 Large families of secreted proteins with known domains

From: A survey of putative secreted and transmembrane proteins encoded in the C. elegans genome

Group Noa Upregulated upon infection Size range (aa)   Typical domain organization Comments
small C-type lectins 236 (184) 83 120-650 clec-1 proteins with a C-type lectin domain
clec-66  
clec-254  
clec-55  
collagens 168 (108) 77 270-500 dpy-5 putative cuticular collagens
ShK proteins 66 (52) 26 120-300 phat-3 proteins containing multiple copies of the ShK toxin domain
Transthyretin-like 56 (46) 24 120-190 ttr-1 transthyretin-related proteins
RcpL-genes 51 (38) 1 300-550 F58E1.4 RcpL is the ligand binding domain in the EGF-receptor (let- 23) and the insulin-receptor (daf- 2)
small CUBproteins 43 (38) 30 300-600 dct-17 many members have no predicted signal peptide
insulins 39 (37) 19 70-130 ins-1 insulin-like peptides
grd- and grl-genes 46 (44) 23 140-450 grl-1 groundhog proteins (hedgehog related proteins)
scl-genes 28 (27) 5 200-250 scl-2 contains lon-1
Ctx-genes 29 (24) 9 300-570   proteins containing multiple copies of a cysteine-rich repeat (Ctx)
abu-9
VOMI proteins 19 (13) 5 100-360 C18D4.4 Vitelline membrane outer layer protein I
large KU/DC proteins 12 (12) 3 920-1800 ZC84.1 (see Figure3 complex proteins) proteins containing tandem copies of Kunitz and DC domains
spp-genes (SapB) 23 (21) 12 100-400 spp-1 saposin-like protein family
wrt-genes 10 (10) 6 180-550 wrt-1 warthog proteins (hedgehogrelated proteins)
  1. aNumber includes family members without SP; number of family members with SP are in brackets.
  2. bNumber of genes upregulated upon at least one infection scenario (see Engelmann et al. 2011).