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Table 2 Large families of putative secreted proteins with ‘domains of unknown function’

From: A survey of putative secreted and transmembrane proteins encoded in the C. elegans genome

Family No of genes Upregulated upon infectionb Size range (aa) Typical domain organization
DUF23 65 (42) 10 400-600 bah-1
nsp-genes 58 (41) 25 35-100 nspd-3
DUF19 51 (42) 14 140-220 C17B7.4
nlp-genes 44 (41) 25 60-180 nlp-1
DUF130 41 (25) 1 140-230 F43C11.2
DUF13 35 (15) 4 200-350 C13A2.4
DUF148 32 (31) 9 150-250 C32H11.5
flp-genes 30 (28) 4 66-170 flp-4
CW 28 (21) 0 230-330 F32D8.2
DUF274 22 (15) 20 340-470 F54E2.1
small DB proteins 18 (17) 11 130-260 F26G1.9
DUF229 15 (11) 4 400-700 F32D8.2
DUF263 13 (11) 3 260-560 R13D7.2
DUF1647 14 (11) 3 340-410 T15D6.9
DUF236 13 (10) 0 200-320 F27C1.3
TF352284c 13 (13) 6 120-160 F17E9.2
DUF316 12 (10) 1 300-750 R01H2.2
DUF273 12 (7) 0 300-400 F31F4.1
DUF271 11 (7) 0 350-400 F28G4.4
DUF268 11 (9) 0 310-380 K04A8.1
DUF870 11 (8) 3 100-200 ZC239.22
DUF672 10 (7) 0 270-340 R05A10.8
DUF1261 10 (10) 9 220-270 F56C9.7
TF319413c 10 (8) 7 123-135 K02E11.5
  1. aNumber includes family members without SP; number of family members with SP are in brackets.
  2. bNumber of genes upregulated upon at least one infection scenario (see Engelmann et al. 2011).
  3. cFamily defined by TreeFam, no recognizable domains.